A 66-year-old woman with a 6-month history of new-onset psoriasis after her first dose of COVID-19 vaccination recently progressed to acute erythroderma accompanied by fever and systemic inflammation. She was started on secukinumab for erythrodermic ps…
Lung cancer remains a leading cause of global cancer-related mortality, with most patients diagnosed at advanced stages. The emergence of immune checkpoint inhibitors (ICIs), specifically targeting PD-1/PD-L1 and CTLA-4 pathways, has revolutionized the…
Allergic rhinitis (AR) is a common clinical chronic inflammatory respiratory disease, in which immune imbalance serves as a core component of its complex pathogenesis. In recent years, the gut-nose axis has emerged as a novel pathway mediating immune c…
IntroductionElevated levels of serum Vitamin D (VitD) and increased expression of its receptor on peripheral blood cells have been reported in individuals who have been exposed to HIV-1 yet remain seronegative (HESN). This study aimed to investigate th…
BackgroundHuman epidermal growth factor receptor-2 (HER2) alterations, including activating mutations and gene amplification, are emerging therapeutic targets in several solid tumors. Trastuzumab–deruxtecan (T-DXd), a HER2-directed antibody-drug conjug…
BackgroundSynovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoinflammatory disorder characterized by osteoarticular and cutaneous manifestations. While tumor necrosis factor-alpha (TNF-α) inhibitors such as adalimumab…
IntroductionAlopecia areata (AA) is a chronic autoimmune-mediated disorder characterized by hair loss from the scalp and/or body. AA patients frequently present with comorbid chronic inflammatory disorders (CIDs), particularly atopic and autoimmune dis…
IntroductionElevated levels of serum Vitamin D (VitD) and increased expression of its receptor on peripheral blood cells have been reported in individuals who have been exposed to HIV-1 yet remain seronegative (HESN). This study aimed to investigate th…
BackgroundHuman epidermal growth factor receptor-2 (HER2) alterations, including activating mutations and gene amplification, are emerging therapeutic targets in several solid tumors. Trastuzumab–deruxtecan (T-DXd), a HER2-directed antibody-drug conjug…
Sepsis has a high incidence and mortality rate, bringing about a high global burden. Recent research has demonstrated that the S100A8/A9–NETosis feedback loop is considered a central regulator of sepsis. However, few studies have integrated these eleme…
