Traumatic brain injury (TBI) is increasingly recognized as a systemic disorder with consequences that extend beyond the central nervous system (CNS) to include clinically relevant cardiac dysfunction. Clinical and experimental evidence indicate that TB…
BackgroundJohne’s disease (JD), caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic enteric disease affecting cattle worldwide, with considerable economic implications for dairy producers. MAP is a robust, intracellular pathogen h…
ObjectiveNeuropsychiatric systemic lupus erythematosus (NPSLE) is a severe and complex complication of systemic lupus erythematosus that affects diagnostic decision-making and treatment strategies. However, the temporal evolution of evidence-based diag…
BackgroundPerforin and granzyme B are key effector molecules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Their expression profiles in hepatobiliary surgical patients and the relative contributions of disease-specific versus host fa…
Gastrointestinal motility disorders are pathologically characterized by dysregulation of the tripartite network comprising the intestinal immune system, the enteric nervous system, and the gut microbiota. Targeted medicines that target important nodes …
BackgroundOne of the most significant recent advancements in cancer immunotherapy is the development of chimeric antigen receptor (CAR) technology. More recently, this approach has been gradually modified for the research associated with various treatm…
BackgroundNeurosyphilis has resurged globally, presenting a significant public health threat, yet challenges in early diagnosis persist. This study aims to evaluate the diagnostic value of C-X-C motif chemokine ligand 1 (CXCL1), C-X-C motif chemokine l…
PurposeTP53 mutations are among the strongest adverse prognostic factors in large B-cell lymphoma (LBCL) treated with chemoimmunotherapy. Whether this unfavorable prognostic impact persists in the era of chimeric antigen receptor (CAR) T-cell therapy r…
BackgroundRadiation-induced intestinal injury denotes structural and functional impairment of the intestines resulting directly or indirectly from ionizing radiation, such as that employed in radiation therapy for malignant tumors in the abdominal or p…
Background and purposeWe describe the clinical characteristics and the therapeutic effect of tocilizumab with Febrile Infection-Related Epilepsy Syndrome (FIRES). FIRES is characterized by super refractory status epilepticus (SRSE) in previously health…
