Colorectal cancer (CRC) is a common malignancy of the digestive tract, and its initiation and progression are closely associated with dysregulation of the tumor immune microenvironment. The CRC immune microenvironment consists of effector immune cells,…
IntroductionPorphyromonas gingivalis (Pg) is a keystone periodontal pathogen linked to adverse pregnancy outcomes that releases outer membrane vesicles (OMV) capable of modulating innate immune responses; however, whether PgOMV reprogram neutrophil ant…
BackgroundBiologic therapies targeting the interleukin-5 (IL-5) pathway improve asthma control and chronic rhinosinusitis with nasal polyposis (CRSwNP) in patients with non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD)…
IntroductionRespiratory syncytial virus (RSV) is an important cause of severe respiratory disease, yet no vaccine is available for older adults in China. This phase 3, randomized, partially blind immunobridging study (NCT06551181) compared a single dos…
BackgroundChronic pancreatitis (CP) is an inflammatory disorder that manifests as pancreatic fibrosis and exocrine insufficiency, and premature activation of trypsinogen to trypsin. Enteropeptidase has emerged as a promising therapeutic target in CP du…
IntroductionCD19 is a key B-cell co-receptor that amplifies B-cell receptor (BCR) signaling and tunes B-cell activation thresholds. How the conformation of the CD19 cytoplasmic domain is regulated to restrain basal and BCR-induced signaling remains inc…
Tuberculosis (TB) is one of the most common infectious diseases caused by Mycobacterium tuberculosis (M.tb). The emergence of multidrug-resistant strains, HIV infection, and poor efficacy of the BCG vaccine have made TB epidemics difficult to control. …
IntroductionBats display diverse antiviral responses, but interferon-β remains poorly characterized in many bat species. Here, we characterized interferon-β from Tadarida brasiliensis (TBIFN-β) in Tb 1 Lu cells, focusing on its sequence features, promo…
Ischemic stroke evolves beyond arterial occlusion through an inflammation-centered network linking neurovascular dysfunction, immune remodeling, metabolic reprogramming, and regulated cell death. These interactions are organized across the hyperacute, …
