Chlamydia muridarum continuously sheds live organisms and persists in the large intestine following intracolonic inoculation, while the live-attenuated chlamydia oral vaccine intrOv, an IFNγ-susceptible mutant of C. muridarum, fails to do so. IFNγ deli…
BackgroundMyocardial ischemia-reperfusion injury (MIRI) presents a significant challenge to the effectiveness of reperfusion therapy in severe ischemic heart disease. One of the core pathological mechanisms of MIRI is NLRP3 inflammasome-mediated cardio…
BackgroundSepsis is a life-threatening syndrome requiring aggressive management, and novel noninvasive biomarkers to enable high-confidence risk stratification of sepsis and to predict sepsis-related outcomes are urgently needed.MethodsQuantitative (li…
Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a poor prognosis despite advances in treatment strategies. Standard treatment regimens induce remissions in many patients, but relapse occurs in approximately half, highlightin…
Hepatitis C virus (HCV) infection remains a major global health burden and a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma. Despite the availability of highly effective direct-acting antivirals, sustained immune dysfun…
Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent episodes of vascular leakage and tissue swelling. Although excessive bradykinin generation has long been considered the central pathogenic mechanism, increasing evidence …
The global surge in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) has necessitated a fundamental shift in clinical management. While patients exhibit favorable prognoses compared to HPV-negative counterparts, balan…
BackgroundIt is documented that Schistosoma mansoni antigens can induce immune responses able to regulate complex diseases. Conversely, the dysregulated inflammatory response in leprosy increases morbidity and leads to reactional episodes, impairing th…
IntroductionChimeric antigen receptor-engineered natural killer (CAR-NK) cells have emerged as a promising strategy for cancer immunotherapy; however, their efficacy against solid tumors remains limited by inefficient tumor trafficking and impaired cyt…
Neutrophil extracellular trap (NET) generation must be tightly controlled as this essential antimicrobial response can also cause tissue damage and contribute to various pathologies. We previously described that neutrophils undergoing NET formation rel…
