Inflammatory bowel diseases (IBD) represent a spectrum of chronic gastrointestinal disorders fueled by a complex multifactorial interplay, where mitochondrial dysfunction has emerged as a critical contributor. The SLC25 family of mitochondrial transpor…
BackgroundSepsis is characterized by profound immune dysregulation, yet the biological significance and clinical application of peripheral immune phenotyping in sepsis remain incompletely defined. This study aimed to define internally identified immune…
Macrophages exhibit phenotypic plasticity, which plays a role in driving tissue injury and promoting mucosal repair in ulcerative colitis (UC). Intestinal macrophages originate from both embryo-derived resident cells and circulating monocytes. Macropha…
BackgroundInterleukin-17A (IL-17A) inhibitors are effective therapies for psoriasis (PsO) and psoriatic arthritis (PsA), yet they may induce or exacerbate inflammatory bowel disease (IBD). Vunakizumab is a novel humanized anti-IL-17A monoclonal antibod…
BackgroundGlobal population aging has driven a marked rise in the co-prevalence of osteoporosis and cognitive impairment, and a bidirectional epidemiological association between the two conditions is now supported by multiple meta-analyses. The shared …
Osteoarthritis is a whole-joint disease involving articular cartilage, synovium, subchondral bone, fat pad, meniscus, blood vessels, and sensory nerves. Its core pathology is not simply passive wear of the cartilage matrix, but rather reciprocal drivin…
BackgroundEpstein–Barr virus (EBV) infects more than 95% of adults and is associated with outcomes ranging from asymptomatic latency to infectious mononucleosis (IM), malignancies, and multiple sclerosis (MS). Conventional ELISA-based EBV serology is o…
Metabolic dysfunction–associated steatotic liver disease (MASLD) is a chronic liver disorder characterized by metabolic abnormalities, persistent low-grade inflammation, and alterations in hepatic immune function. In addition to lipid accumulation and …
BackgroundThe COVID-19 pandemic and associated containment measures could have influenced children’s immune system development through reduced microbial exposure and lifestyle changes. Hematological parameters and immunoglobulin E (IgE) are key indicat…
