BackgroundAnkylosing spondylitis (AS) is a chronic inflammatory arthropathy with heritability estimated at approximately 90%, yet the effector genes and regulatory mechanisms beyond the well-established HLA-B*27 association remain incompletely defined….
Guillain-Barré syndrome (GBS) is an immune-mediated acute inflammatory peripheral neuropathy. While it is well-established that its typical manifestations involve the peripheral nerves, it is noteworthy that involvement of the central nervous system an…
BackgroundIgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and a leading cause of end-stage kidney disease, yet disease-specific therapeutic options remain limited. Emerging evidence implicates gut microbiota dysbiosis and…
BackgroundVitiligo is a common depigmenting disorder frequently misdiagnosed due to its visual similarity to other hypopigmentary conditions. While artificial intelligence (AI) has shown promise in dermatological image analysis, most models lack interp…
The advent of cancer immunotherapy has fundamentally restructured the oncological paradigm, moving away from agents that directly target tumor cell kinetics toward strategies that empower the host immune system to recognize and eliminate malignancy. Ce…
Anti-glomerular basement membrane (anti-GBM) disease during pregnancy is rare and often life-threatening. We report a G4P1 woman who developed atypical anti-GBM disease at 13 weeks of gestation. Serial kidney biopsies demonstrated a reduction in active…
The adaptive immune system continuously encounters antigens from a wide range of sources, including pathogens, self-tissues, tumors, and environmental agents. While extensive studies have characterized how lymphocytes respond to antigen binding, most e…
IntroductionTocilizumab (TCZ), an anti-interleukin-6 receptor (IL-6R) biologic agent, is commonly used to treat systemic juvenile idiopathic arthritis (sJIA); however, the optimal dosing strategy for susceptible children and the timing of administratio…
BackgroundHepatocellular carcinoma (HCC) patients with bone metastasis-induced paraplegia have an extremely poor prognosis. The potential for neurological recovery following immunotherapy and subsequent rehabilitation in this population remains unclear…
BackgroundPatients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) remain at residual cardiovascular risk. The pan-immune-inflammation value (PIV), integrating neutrophil, platelet, monocyte, and lymphocyte counts…
