During systemic inflammation, neutrophil extracellular traps (NETs) capture pathogens but, in the long-term, can cause bystander damage to the vasculature. Another hallmark of sepsis in the blood is erythrocyte damage/alterations, often leading to hemo…
Chimeric antigen receptor (CAR) T-cell therapy has undergone great advances since the development of the first-generation CAR in the early 1990s. Currently there are seven FDA approved CAR T-cell therapies for the treatment of hematological malignancie…
Seminal plasma (SP) is a complex immune modulator within the female reproductive tract of several species. In sheep, it can restore the fertility of cryopreserved sperm and is necessary for the fertility of epididymal sperm following cervical artificia…
Acute traumatic injury triggers complex systemic inflammatory and immune responses and remains a leading global cause of mortality and disability. Traditionally viewed primarily as passive oxygen carriers, erythrocytes are now emerging as key participa…
IntroductionDietary supplementation with functional starches serves as a promising intervention strategy for immune regulation, yet the immunomodulatory efficacy and underlying mechanisms of newly developed modified starch derivatives remain to be furt…
BackgroundClear cell renal cell carcinoma (ccRCC) exhibits substantial molecular and immune heterogeneity. Mast cells participate in tumor-microenvironment remodeling, but the prognostic relevance of mast cell-associated apoptosis-related transcription…
Nanopore sequencing has emerged as a transformative technology, offering unprecedented speed, ultra-long reads, and portability at a comparatively low cost. These attributes are fundamentally reshaping clinical diagnostics and personalized medicine. Th…
Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nasal cavity and paranasal sinuses. Eosinophilic CRS (ECRS) is a refractory subtype characterized by persistent type 2 inflammation. Epidemiological and animal studies suggest that C…
