BackgroundVitiligo is a chronic autoimmune disorder characterized by CD8+ T cell-mediated destruction of melanocytes. It affects up to 2% of the global population and has a profound psychosocial impact. Over the past two decades, advances in understand…
The transient receptor potential canonical 3 (TRPC3) channel plays a pivotal role in macrophage-mediated inflammatory signaling by regulating intracellular calcium dynamics. This study identifies phosphorylation at serine 712 (S712) by protein kinase C…
Necrotizing enterocolitis (NEC) is a severe intestinal infectious disease. m6A modification plays a critical role in intestinal homeostasis and infection, while its role in NEC remains unclear. This study aimed to investigate the landscape of m6A modif…
IntroductionInfection-induced orchitis, a leading cause of acquired male infertility affecting 8%–12% of couples globally, is driven by unresolved inflammatory responses following bacterial infection.MethodsWe employed uropathogenic Escherichia coli (U…
Progressive allograft fibrosis remains a major obstacle in kidney transplantation. Early identification of patients at high risk could be instrumental to improve outcomes. Here, we investigated Lysyl oxidase like 2 (LOXL2) as a biomarker for graft fibr…
Mitochondrial fusion and fission regulate mitochondrial morphology and homeostasis, both of which are essential for maintaining cellular health. Free mitochondria and mitochondrial-containing extracellular vesicles have emerged as key mediators of path…
IntroductionHypertensive heart disease (HHD) is characterized by chronic pressure overload leading to myocardial remodeling and fibrosis. While inflammation and cell death pathways contribute to fibrogenesis, the mechanistic role of neutrophil extracel…
Understanding the activation mechanisms of γδ T cells in colorectal cancer (CRC) is critical for harnessing their therapeutic potential. Here, using an atlas of human CRC-infiltrating γδ T cells that we built by integrating multiple single-cell RNA-seq…
IntroductionKidney transplantation is the preferred treatment for end-stage renal disease, but immune-mediated graft dysfunction remains a major barrier to long-term success. Conventional indicators such as serum creatinine and proteinuria are not immu…
