IntroductionBreast cancer (BC) remains a leading cause of cancer-related deaths, with resistance to therapy driving tumor progression. While immune checkpoint inhibitor (ICI) therapy is effective in some breast cancers, the heterogeneity of treatment r…
Regulatory T (Treg) cells are a specialized subset of CD4+ T cells indispensable for the establishment and maintenance of immunological tolerance. Treg cells employ diverse mechanisms of immune regulation mediated by a broad repertoire of immunosuppres…
Minocycline is a tetracycline antibiotic with profound anti-inflammatory activity directed primarily against microglial cells and macrophages. Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as an important target of mino…
Myasthenia gravis (MG) is an antibody-mediated autoimmune disorder of the neuromuscular junction in which weakness fluctuates across symptom domains, daily activities, and treatment cycles. Established measures such as the Quantitative Myasthenia Gravi…
BackgroundInflammation after lumbar disc herniation (LDH) may contribute to radicular pain while also participating in resorption of herniated disc material. Whether circulating immune profiles are associated with these endpoint-specific recovery patte…
BackgroundIncreasing antimicrobial resistance and the high health and economic burden of frequent, recurring urinary tract infections (rUTIs) drive the need for an efficacious UTI vaccine. Most UTIs are caused by uropathogenic E. coli (UPEC) expressing…
ObjectiveCytomegalovirus (CMV) infection can cause severe morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Letermovir is recommended as CMV prophylaxis for allo-HSCT recipients. This study a…
BackgroundInflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by dysregulated mucosal immunity. Despite major advances in therapies, a high proportion of patients do not achieve or sustain remission. Cellular immunother…
ObjectiveTo characterize shared immune-associated programs between sepsis and systemic lupus erythematosus (SLE), define the cellular context of prioritized candidate genes, and functionally evaluate SIGLEC1 in macrophage inflammatory responses.Methods…
