Hypertension affects approximately 1.3 billion adults worldwide, yet the control rate remains below 20%, highlighting the limitation of current therapies that primarily lower blood pressure without targeting the underlying pathophysiological mechanisms…
BackgroundAcute pontine infarction significantly impacts neurological function and prognosis. Recent studies suggest that low-grade inflammation (LGI) may play a critical role in influencing recovery outcomes. However, the relationship between LGI and …
IntroductionSeveral studies have reported an up-regulation of interleukin (IL)-36 in the serum of patients with systemic lupus erythematosus (SLE). Here, we sought to define the mechanisms whereby IL-36 may contribute to the over-activation of type I I…
IntroductionThe discovery of induced pluripotent stem cells (iPSCs) revolutionized the field of translational medicine by enabling the reprogramming of adult somatic cells into a pluripotent state. From personalized disease models to innovative cell th…
BackgroundImmune checkpoint inhibitors (ICIs) have demonstrated efficacy in the treatment of resectable and advanced gastric cancer. However, their effectiveness in initially unresectable gastric cancer remains unclear. This study aims to evaluate the …
Autoimmune and allergic diseases represent two major categories of immune-mediated disorders that collectively impose a significant global health burden. Although driven by distinct triggers—aberrant responses against self-antigens in autoimmunity and …
Resistance to chemotherapy and targeted therapy in cancer is largely due to evasion of apoptosis, but ferroptosis—an iron-dependent form of regulated cell death driven by lipid peroxidation—offers a promising alternative, particularly in aggressive and…
ObjectiveThis study aims to develop a deep learning (DL)-based multimodal framework that integrates magnetic resonance imaging (MRI), clinical, and laboratory data to predict programmed death ligand 1 (PD-L1) and vascular endothelial growth factor (VEG…
