Peritoneal metastasis is the most devastating form of progression of gastric cancer, characterized by strong immune suppressive properties and resistance to treatment. Tumor-associated macrophages (TAMs) are the main population of immune cells in the p…
IntroductionRosacea is a chronic inflammatory skin disorder characterized by neurovascular instability and dysregulated innate immunity. Although mast-cell activation is increasingly recognized as a central pathogenic feature, the neuroimmune mechanism…
Glioblastoma (GBM) is the most aggressive type of primary brain tumour in adults, and after treatment, it is also difficult to know whether a person’s health has improved. Pseudoprogression (PsP), particularly following radiotherapy and combination the…
Hepatocellular carcinoma (HCC), a malignancy with high global morbidity and mortality, has therapeutic resistance as a major focus of both clinical and basic research. In recent years, protein post-translational modifications (PTMs), key regulators of …
BackgroundBulk RNA-sequencing of thoracic tumours is routine, but the T-cell receptor (TCR) repertoires it contains are rarely re-mined with a uniform pipeline, and library-prep compatibility for productive V–J-spanning assembly is rarely audited at th…
Pain in osteoarthritis (OA) is not explained adequately by cartilage loss or radiographic severity. Synovial inflammation, tissue damage, and neural plasticity interact across the joint, dorsal root ganglia, spinal cord, and brain to shape the intensit…
BackgroundApproximately 5–10% of healthy, immunocompetent individuals are low- or non-responders to the HepB vaccine. The mechanism remains obscured. Among responders, immunity may wane over time, becoming undetectable in some. However, in some vaccine…
Progressive multiple sclerosis (MS) remains a major therapeutic challenge because disability often continues to accumulate despite effective control of relapses and new focal inflammatory lesions. This dissociation suggests that progression is driven n…
Periodontitis, a chronic inflammatory disorder, results in tooth loss and adversely affects oral and systemic health. Current therapies fail to effectively regenerate bone loss caused by inflammation. Human stem cell-derived exosomes have emerged as im…
Platelet Factor 4 (PF4) is a CXC chemokine abundantly sequestered within platelet α-granules. Its modulatory roles in age-related dysfunction across cognitive, immune, and hematopoietic systems have garnered increasing research attention in recent year…
