BackgroundHow infection shapes recall responses in the setting of preexisting influenza virus hemagglutinin (HA) stem-focused immunity has important implications given the known impact of imprinting on future immune responses. Adoption of an HA-based u…
IntroductionImmunosuppressed women with human papillomavirus (HPV)-related genital disease are at increased risk of anal squamous cell carcinoma (ASCC), yet optimal risk stratification and screening strategies remain poorly defined. The aim of this stu…
BackgroundImmune checkpoint inhibitor (ICI)-based induction therapy followed by definitive radiotherapy has emerged as a promising treatment strategy for patients with unresectable locally advanced esophageal squamous cell carcinoma (LA-ESCC). However,…
ObjectiveThe gut-kidney axis has emerged as a critical area of investigation. However, the compartment-specific regulatory mechanisms of gut microbiota metabolites within the glomerular and tubulointerstitial regions of diabetic kidney disease (DKD) re…
IntroductionBenzo[a]pyrene (B[a]P), a widespread polycyclic aromatic hydrocarbon (PAH), is a major aquatic pollutant with known toxic effects. However, its immunotoxicity during early fish development remains poorly understood. This study investigated …
BackgroundDry eye disease (DED) and anxiety are prevalent disorders that often coexist, yet the molecular mechanisms underlying their comorbidity remain inadequately understood. This study sought to elucidate the convergent genes, pathways, and immune …
BackgroundAlthough immune checkpoint inhibitor (ICI) therapy has revolutionized cancer treatment, the incidence of cardiac toxicity associated with ICIs remains unclear. This study aimed to evaluate the cardiac toxicity risks associated with ICI and id…
ObjectiveWe aimed to quantify the relationship between CSF IL-6 compartmentalization and MRI lesion extent in patients with MOG-CCE, and to evaluate the CSF/serum IL-6 ratio as a biomarker of CNS-compartmentalized inflammation.MethodsEight MOG-CCE pati…
BackgroundDropped head syndrome (DHS) is a rare, disabling chin-on-chest deformity caused by severe cervical extensor weakness. The etiologic spectrum is dominated by peripheral myopathies, motor neuron disease, and myasthenia gravis; central nervous s…
BackgroundAlthough multiple studies have confirmed that adjusting the time-of-day (ToDA) of immunotherapy and timing interval (TI) of chemoimmunotherapy can improve long-term outcomes in patients with advanced non-small cell lung cancer (NSCLC), whethe…
