BackgroundCarcinoembryonic antigen (CEA) is overexpressed in most colorectal cancers (CRC) and serves as a promising immunotherapeutic target. However, current immune cell therapies against CRC show limited clinical efficacy, and the lack of renewable,…
AimsWe investigated the incidence of infections and hypogammaglobulinemia (HGG) in patients with myasthenia gravis (MG) receiving long-term low-dose rituximab (RTX) maintenance therapy and identified related risk factors.MethodsThis single-center retro…
BackgroundAir pollutants and lead (Pb) are widespread environmental risk factors that may disrupt children’s intestinal immune homeostasis. However, the immunoregulatory responses of intestinal mucosal immunity to chronic co-exposure remain poorly unde…
BackgroundAPDS is a combined immunodeficiency disorder, characterized by impaired antibody production and lymphoproliferation, with a high risk of malignancy and autoimmunity. The disease may be caused by autosomal dominant gain-of-function variants in…
PurposeAdult thymic involution has been implicated in impaired antitumor immunity, but whether hepatocellular carcinoma (HCC) is associated with structural thymic involution in humans remains unclear. This study evaluated parameters of thymic CT imagin…
BackgroundGastrointestinal symptoms of IgA vasculitis (IgAV) patients are relatively common. These symptoms are similar to those of acute abdomen, coupled with the poor expressive ability of young children and children, which leads to the possibility o…
IntroductionMultiple sclerosis (MS) is associated with compartmentalized B-cell responses in the cerebrospinal fluid (CSF), where CXCR3+ B cells contribute to intrathecal immune activity and tissue injury. Zinc is an important regulator of immune-cell …
BackgroundClinical and genetic evidence on the association between atopic dermatitis (AD) and subsequent psoriasis remains conflicting, and it is unclear whether this risk is modified by systemic treatments. Recent reports suggest that type 2-targeted …
ImportanceBoth epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and PD-1/PD-L1 inhibitors are widely used in non–small cell lung cancer (NSCLC). The safety of their combination, particularly the risk of interstitial pneumonitis (…
BackgroundCellular immunotherapies—including chimeric antigen receptor T-cell (CAR-T) therapies and adoptive transfer of virus-specific T lymphocytes (VSTs) — have transformed the treatment of refractory hematological malignancies and post-transplant i…
