Wound healing is a complex process involving different cell types, molecules and stages in the dermis, epidermis and associated microbiome. Chronic wounds caused by pressure, diabetes, or immunodeficiency often have huge economic and therapeutic costs….
BackgroundObesity is a chronic metabolic disease characterized by increased oxidative and nitrosative stress, as well as enhanced protein glycation, all of which adversely affect the skin. Although the ketogenic diet (KD) has been shown to modulate oxi…
Recent studies have identified antigen-experienced TCF1+PD-1+ lineage-negative (lin-) CD4 T cells in several tumor types. Strictly, stemness requires durable self-renewal and multipotent output demonstrated at the single-cell level; these criteria have…
BackgroundAmyotrophic lateral sclerosis (ALS) lacks reliable and minimally invasive biomarkers for early diagnosis. m6A-associated single-nucleotide polymorphisms (m6A-SNPs) may influence RNA methylation and gene expression, offering opportunities to i…
Radiation-induced lung injury (RILI) remains a major dose-limiting toxicity of thoracic radiotherapy. In the era of combination anticancer therapy, its recognition and management have become more difficult. Systemic treatments can cause pneumonitis or …
BackgroundFibroblast activation and extracellular matrix deposition are central features of IPF, but the molecular programs that sustain pathogenic fibroblast states remain incompletely defined. NUFIP1 has been implicated in ribonucleoprotein biology a…
The limited efficacy of immunotherapy in solid tumors is increasingly recognized to reflect not only molecular and cellular immune suppression, but also profound mechanical abnormalities within the tumor microenvironment (TME). Emerging evidence indica…
BackgroundHighly sensitized kidney transplant candidates possess preformed anti-human leukocyte antigen (HLA) antibodies that substantially reduce their likelihood of receiving a compatible deceased-donor organ. Manual virtual crossmatch (VXM) workflow…
Severe COVID-19 is strongly associated with a high incidence of secondary bacterial, fungal, and viral infections, which substantially contribute to prolonged hospitalization and increased mortality. Although cytokine storm characterized by elevated le…
Regulated cell death (RCD) is closely involved in immune dysregulation and organ injury during sepsis, yet the coordinated transcriptional features of multiple RCD modalities and their relevance to sepsis heterogeneity remain insufficiently characteriz…
