Clostridioides difficile polysaccharides (PSs) represent useful tools for the study of C. difficile pathogenesis. Water-soluble PS-I (pentaglycosyl-phosphate repeats) and PS-II (hexaglycosyl-phosphate repeats) and phenol-soluble lipoteichoic acid (LTA)…
ObjectiveThrombocytopenia in APS is often regarded primarily as a bleeding-related manifestation, but the relationship between platelet-count severity and thrombotic manifestations remains uncertain. We evaluated the association between severe thromboc…
Emphysematous pancreatitis (EP) is a severe and life-threatening complication of pancreatitis characterized by gas formation within pancreatic tissues, which often results from bacterial infection. This condition poses significant challenges due to its…
BackgroundMacrophage-mediated inflammation critically determines malaria pathology. Although pyroptosis contributes to host defense, excessive activation induces severe immunopathology. The precise pyroptotic pathways in splenic macrophages during Plas…
BackgroundOsteoporosis (OP) is a frequent comorbidity in rheumatoid arthritis (RA). This study compared the performance of RA disease-activity scores with complete blood count (CBC)-derived indices for identifying prevalent OP.MethodsWe retrospectively…
Chronic pulmonary diseases, including cystic fibrosis, chronic obstructive pulmonary disease, and chronic bronchitis, as well as ventilator-associated pneumonia, are characterized by persistent infection of mucus-laden airways. Pseudomonas aeruginosa (…
BackgroundMicro- and nanoplastics (MNPs) are increasingly detected in human tissues, raising concerns regarding their potential impact on immune cell function. Monocytes are among the first immune cells to encounter and internalize these particles. How…
IntroductionTyrosine kinase inhibitors targeting the c-KIT receptor are pivotal in the targeted therapy of malignancies such as gastrointestinal stromal tumors (GIST). The bioactivity of these inhibitors is typically quantified by the half-maximal inhi…
IntroductionInborn errors of immunity (IEI) are associated with an increased risk of malignancy; however, the spectrum, timing, and outcomes of cancer across different IEI subgroups remain incompletely characterized.MethodologyWe conducted a retrospect…
