IntroductionInborn errors of immunity (IEI) are associated with an increased risk of malignancy; however, the spectrum, timing, and outcomes of cancer across different IEI subgroups remain incompletely characterized.MethodologyWe conducted a retrospect…
BackgroundPediatric idiopathic nephrotic syndrome (INS) involves complex immunological mechanisms, and clinical presentation may be influenced by environmental factors and access to medical services. The impact of the COVID-19 pandemic on its clinical …
BackgroundRheumatoid arthritis (RA) is characterized by synovial inflammation, synovial fibroblast (SF) activation, and joint destruction. Activated SFs acquire proliferative and invasive properties and interact with macrophages to maintain the inflamm…
BackgroundX-linked hyper-immunoglobulin M (XHIGM) syndrome is a rare primary immunodeficiency caused by mutations in the CD40 ligand gene (CD40LG), characterized by defective T-cell-dependent B-cell class-switch recombination. Patients typically presen…
BackgroundSecondary immunodeficiency (SID) arises from malignancy, immunomodulatory therapies, organ dysfunction, chronic infection, malnutrition, and aging. Despite its increasing prevalence, SID remains conceptualized within disease-specific silos, r…
Largemouth bass ranavirus (LMBV) and Nocardia seriolae are major pathogens affecting largemouth bass (Micropterus salmoides), causing significant economic losses. In this study, recombinant yeasts expressing the fibronectin-binding protein A (FHA) of N…
BackgroundCartilage injury is a hallmark of osteoarthritis (OA). erb-B2 receptor tyrosine kinase 2 (ERBB2) has been reported to be involved in mediating the therapeutic effects of polyphenols in orthopedic diseases. This study aimed to investigate the …
p38γ and p38δ (p38γ/p38δ) have emerged as important regulators of immune function; however, their specific contribution to adaptive humoral responses remains poorly understood. Based on previous evidence that global p38γ/p38δ deficiency impairs antibod…
Male and female immune systems differ in composition and function across the entire life course, shaping susceptibility to infection, autoimmunity, allergy, neurodegeneration, cancer, and responses to vaccines and immunotherapies. Despite decades of ob…
