ObjectiveThis study aimed to characterize molecular subtypes of Papillary thyroid carcinoma (PTC) and identify novel therapeutic targets and potential therapeutic compounds.MethodsWe performed integrative analysis of TCGA data, including consensus clus…
BackgroundBrain metastases (BrMs) represent the most common intracranial tumors, which occur at a significantly higher incidence than primary brain neoplasms. Although some studies addressed the modulation of endothelial cells (ECs) and macrophages in …
ObjectivesThis study investigated the prevalence of thyroid dysfunction—including clinical and subclinical hyperthyroidism, clinical and subclinical hypothyroidism, and euthyroid sick syndrome (ESS)—and its associated risk factors in patients with syst…
CAR T cell therapies have shown clinical success in several tumor types, though not in breast cancer, for which advanced stages remain incurable. CD70 is expressed in a broad range of solid tumor types and is emerging as a molecular target for CAR T ce…
ObjectivesTo explore clinical and ultrasonographic features preceding the development of a difficult-to-treat (D2T) phenotype in a real-world cohort of patients with psoriatic arthritis (PsA).Materials and methodsIn this retrospective cohort study, con…
BackgroundChronically activated T-effector (Teff) cells can play a pivotal role in T-cell-mediated diseases including systemic lupus erythematosus subsets, lupus nephritis and graft-vs-host disease (GvHD). Since T cells require diverse costimulation si…
Parasitic eosinophilic lung disease is characterized by eosinophil infiltration and dysregulated immune responses, posing significant challenges due to its complex immunoregulatory mechanisms which remain incompletely understood. This review explores t…
BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease of the upper airway driven by diverse inflammatory cells and mediators. This study aimed to characterize the inflammatory landscape of CRSwNP and to identify …
Estrogen deficiency is a major risk factor for degenerative disorders of the musculoskeletal system in postmenopausal women, while ferroptosis, an iron-dependent form of programmed cell death, has been implicated in the pathogenesis of various osteoart…
BackgroundTrigger finger (TF) is a common hand disorder traditionally viewed as a localized mechanical condition. Recent evidences suggests potential links between tenosynovial pathology and systemic inflammatory diseases, especially rheumatoid arthrit…
