BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease of the upper airway driven by diverse inflammatory cells and mediators. This study aimed to characterize the inflammatory landscape of CRSwNP and to identify …
Estrogen deficiency is a major risk factor for degenerative disorders of the musculoskeletal system in postmenopausal women, while ferroptosis, an iron-dependent form of programmed cell death, has been implicated in the pathogenesis of various osteoart…
BackgroundTrigger finger (TF) is a common hand disorder traditionally viewed as a localized mechanical condition. Recent evidences suggests potential links between tenosynovial pathology and systemic inflammatory diseases, especially rheumatoid arthrit…
BackgroundSequential conditioning allogeneic hematopoietic stem cell transplantation (allo-HSCT) regimens might offer improved disease control in high-risk myeloid patients. But concerns remain regarding toxicity, infection risk and delayed immune reco…
Long-term immunosuppressant use after solid organ transplantation causes serious complications, including chronic rejection, infection, malignancy, and metabolic disorders, which has motivated the clinical pursuit of immune tolerance induction. Sequent…
BackgroundChimeric antigen receptor (CAR) T-cell therapy has shown limited efficacy against solid tumors due to antigen heterogeneity and scarcity of tumor-specific targets.MethodsTo address those challenges, we report a covalent CAR-T strategy that ac…
BackgroundTacrolimus is a core immunosuppressant in organ transplantation, but its narrow therapeutic window and significant pharmacokinetic variability hinder precision dosing. Although CYP3A5-guided strategies have established clinical relevance for …
BackgroundAutoimmune skin diseases exhibit chronicity and site-specific relapse that are not fully explained by genetic susceptibility or cytokine signaling alone. Emerging evidence suggests that epigenetic reprogramming of skin-resident immune cells c…
ObjectiveTo investigate the associations of iron-related parameters, including serum ferritin (SF), serum iron (SI), and transferrin saturation (TSAT), with the development of sepsis-associated acute kidney injury (SA-AKI).MethodsThis retrospective stu…
BackgroundAcute gouty arthritis (AGA) is an acute inflammatory disorder triggered by the deposition of monosodium urate crystals (MSU) in the joints, clinically characterized by severe pain and transient limitation of joint mobility. Without proper int…
