Keloid, as a unique form of pathological scar, involves complex interactions across multiple dimensions in its pathogenesis, including genetic susceptibility, epigenetic regulation, immune microenvironment disorders, metabolic reprogramming, abnormal m…
BackgroundImmune checkpoint inhibitor (ICI)-associated myocarditis (ICI-M) is a rare but potentially lethal immune-related adverse event (irAE). Early identification of fulminant (severe) cases remains challenging, and the peripheral immune derangement…
Cutaneous wound healing is not only a spatially coordinated reparative process but also a temporally organised immune programme shaped by circadian rhythms. This Review summarises how the central clock, peripheral clocks and core clock genes regulate t…
IntroductionWith advancing safety profiles in allogeneic hematopoietic stem cell transplantation (allo-HSCT), determining whether HLA-matched siblings remain the optimal donor choice for older adults (≥40 years) and whether haploidentical-HSCT demonstr…
ObjectiveTo compare the efficacy and safety of topical ocular therapies for Sjögren’s syndrome–related dry eye disease.MethodsPubMed, Embase, Web of Science, Cochrane Central, CNKI, Wanfang, VIP, and CBM were searched from inception to April 29, 2026. …
BackgroundDiabetic kidney disease (DKD) is a prevalent microvascular complication with limited therapeutic options. This study aimed to identify biomarkers associated with microplastic-associated plasticizers in DKD and to explore their potential molec…
IntroductionAn increasing number of studies focus on anti-tumor immune responses. In acute myeloid leukemia (AML), blasts and immune cells, such as T cells, are frequently studied together in the same leukocyte sample. While hemolysis is the clinical s…
Microsatellite-stable (MSS) colorectal cancer (CRC), comprising ~85–90% of cases, remains almost universally refractory to PD-1/PD-L1 monotherapy (objective response rate 5–10%), in stark contrast to the marked efficacy of immune checkpoint inhibitors …
Endometriosis (EM) is a chronic, inflammatory gynaecological disorder defined by the presence of endometrial-like tissue outside the uterine cavity, most frequently affecting the ovaries, peritoneum, and uterosacral ligaments. Despite its prevalence an…
