BackgroundPararamosis, or pararama-associated phalangeal periarthritis, is a neglected tropical disease affecting rubber tappers in the Amazon, caused by contact with the urticating bristles of the Premolis semirufa caterpillar. This condition leads to…
IntroductionTuberculosis (TB), caused by Mycobacterium tuberculosis, is a highly heterogeneous disease driven by the pathogen’s adaptive mechanisms to subvert the host immune response. Identifying biomarkers that can stratify disease severity remains a…
BackgroundChronic low-grade inflammation is a pathophysiological hallmark of various chronic diseases, including cardiovascular diseases, metabolic disorders, and cancers. Regular physical exercise is recognized as an effective strategy to mitigate sys…
ObjectivesBelimumab has emerged as a therapeutic option for lupus nephritis (LN); however, real-world evidence on its effectiveness remains limited. This study aimed to evaluate the effectiveness and safety of belimumab and to identify renal and immuno…
IntroductionNutritional supplementation with ω-3 polyunsaturated fatty acids has shown potential benefits in inflammatory bowel disease, although clinical responses remain inconsistent. This may be partly due to the limited conversion of ω-3 PUFAs into…
The maintenance of local immunity requires stable tissue adaptation, implying that persistent environmental cues must continuously reinforce niche-specific immune programs. Microbiota-derived metabolites are increasingly recognized as such cues, acting…
BackgroundPredictors for the successful eradication of neutralizing anti-FVIII alloantibodies (inhibitors) in hemophilia A patients receiving immune tolerance induction (ITI) therapy remain limited. Maternal microchimerism (MMc) showed potential to pro…
IntroductionThe diversity of environmental microbial exposure is a key driver of immune maturation and host defense; however, its impact on brain immunity and neurodegenerative diseases remains poorly documented. MethodsHere, we show that controlled in…
BackgroundChronic low-grade inflammation drives cardiometabolic diseases and has a strong genetic basis. Most genome-wide association studies (GWAS) have focused on European populations, limiting knowledge of the genetic influences on inflammation in a…
BackgroundIntrathecal immunoglobulin G synthesis (ITGS) is important for MS diagnosis. Oligoclonal bands (OCB) have demonstrated sensitivity and specificity, but their complexity necessitates their analysis in specialized laboratories. Measuring the ka…
