While the link between childhood obesity and central precocious puberty (CPP) is well documented, the immune-mediated mechanisms that may precipitate earlier pubertal onset remain incompletely understood. This review proposes hypothalamic neuroimmune r…
PurposeTo systematically assess the prognostic significance of baseline 18F-fluorodeoxyglucose positron emission tomography/computed tomography ([18F] FDG PET/CT) metabolic parameters in patients with non-small cell lung cancer (NSCLC) undergoing immun…
BackgroundThe efficacy and safety of perioperative immune checkpoint inhibitors (ICIs) combined with chemotherapy for resectable gastric/gastroesophageal junction (GEJ) cancer remain to be definitively established. This meta-analysis aimed to synthesiz…
Triple-negative breast cancer (TNBC) represents a highly aggressive breast cancer subtype characterized by the absence of estrogen receptor, progesterone receptor, and HER2 expression, resulting in limited targeted therapeutic options and poor clinical…
IntroductionSevere COVID-19 disease is characterised by a state of hyperinflammation. As key producers of inflammatory mediators in blood, altered inflammatory activity of monocytes within some individuals may contribute to adverse disease outcomes.Met…
BackgroundAnaphylaxis is a severe, fast-onset hypersensitivity reaction. Studies have shown that neutrophils play an important role in the acute phase of anaphylaxis. Activated neutrophils can release neutrophil extracellular traps (NETs); however, the…
Pediatric central precocious puberty (CPP) is driven by premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, along with immune-inflammatory imbalance, metabolic dysfunction, obesity, and gut microbiota-derived signals. According to tr…
SARS-CoV-2 Omicron evolution continues to erode antibody-mediated immunity, but whether infection with antigenically distinct lineages simply amplifies pre-existing memory or redirects humoral recognition toward newly evolved antigenic space remains un…
BackgroundGut microbiota alterations have been implicated in the progression of metabolic syndrome (MetS), which increases the risk of cardiovascular disease (CVD) and is influenced by lifestyle factors. However, the specific gut microbiota changes and…
Flap ischemia-reperfusion injury (IRI) and chronic refractory wounds are intractable clinical challenges in the field of wound repair. Both pathological conditions share a core pathological hallmark: disrupted homeostasis of the local wound inflammator…
