inmunoadmin

Circulating Platelet-Natural Killer Cell Complexes are Elevated in People Living with HIV on Antiretroviral Therapy​Brita Ostermeier on 20 de August de 2026 at 10:00

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J Leukoc Biol. 2026 Aug 20:qiag116. doi: 10.1093/jleuko/qiag116. Online ahead of print. ABSTRACT Natural killer (NK) cells stand as a critical pillar in the innate immune defense against viral infections, particularly human immunodeficiency virus (HIV). However, during HIV infection, NK cells demonstrate profound dysfunction, undermining effective immune control and accelerating disease progression along with viral … Read more

CD55 downregulation identifies a pathogenic CD4+ T cell axis linked to p38 MAPK signaling in rheumatoid arthritis

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J Immunol. 2026 Aug 4;215(8):vkag229. doi: 10.1093/jimmun/vkag229. ABSTRACT CD4+ T cell dysfunction plays a critical role in the pathogenesis of rheumatoid arthritis (RA). In this study, we investigated the expression, phenotypic characteristics, and potential clinical significance of CD55, a membrane-bound complement regulatory protein, in peripheral blood CD4+ T cells from RA patients. Flow cytometric analysis … Read more

PD-L1 restrains T-cell immunity in Nile tilapia by suppressing activation-induced fatty acid synthesis

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J Immunol. 2026 Aug 4;215(8):vkag236. doi: 10.1093/jimmun/vkag236. ABSTRACT The programmed death ligand 1/programmed cell death 1 (PD-L1/PD-1) serves as a critical immune checkpoint in T cell-mediated immune responses, playing a central role in maintaining peripheral immune tolerance and homeostasis. Although early vertebrates lack a PD-1 homolog and they retain PD-L1, the functional significance and regulatory … Read more

Impact of Chronic Infection‐Induced Inflammation on TREG Cell Homeostasis. [[{“value”:”Zachary R. Lanzar, Daniel L. Aldridge, Julia N. Eberhard, Elisa Cruz‐Morales, Isabella O. Conway, Molly E. Bunkofske, Joseph A. Pereira, Melissa Parker, Chryssa Kanellopoulou, Christopher A. Hunter”}]]

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Acute T. gondii infection caused thymic atrophy, reduced IL-2, and a sharp decline in Treg cells. As infection resolves, IL-2 and thymic function recover, which partially restores Tregs. Fate-mapping shows thymic Treg generation remains intact, but surviving peripheral Tregs chiefly rebuild the pool. Antiparasitic treatment can enhance thymic Treg generation. ABSTRACT Thymically-derived regulatory T (Treg) … Read more

CARM1: an epigenetic brake on cDC1-mediated antitumor immunity. Congliang Chen

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Trends Immunol. 2026 Aug 19:S1471-4906(26)00215-2. doi: 10.1016/j.it.2026.08.002. Online ahead of print. ABSTRACT The underlying mechanism of tumor microenvironment-induced dysfunction of conventional type 1 dendritic cells (cDC1) remains unclear. Zhang et al. identify transforming growth factor β-driven coactivator-associated arginine methyltransferase 1 (CARM1) as an epigenetic inhibitor of cDC1 cross-presentation. CARM1 is a cell-intrinsic brake, and its … Read more

Neurons as cytokine sensors in the central nervous system. Audrey Kahn

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Trends Immunol. 2026 Aug 19:S1471-4906(26)00191-2. doi: 10.1016/j.it.2026.07.012. Online ahead of print. ABSTRACT Cytokines are key messenger molecules that bridge the nervous and immune systems through a bidirectional signalling network. Beyond their roles in development and homeostasis, neuronal cytokine sensing allows the central nervous system (CNS) to detect early immune perturbations, such as those triggered by … Read more

Breast milk IgG: ‘it does a baby good’. Marion E G Brunck

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Trends Immunol. 2026 Aug 19:S1471-4906(26)00193-6. doi: 10.1016/j.it.2026.07.014. Online ahead of print. ABSTRACT Maternal milk antibodies are garnering increasing interest. While IgA dominates the milk antibody literature, IgG is emerging as a critical source of protection for the hyporesponsive neonate against life-threatening infections and as an important factor in instructing developing immunity. In this forum article, … Read more

Exercise-driven microbiome changes regulate host immunity. Catherine M Phelps

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Trends Immunol. 2026 Aug 18:S1471-4906(26)00214-0. doi: 10.1016/j.it.2026.08.001. Online ahead of print. ABSTRACT Exercise reshapes host physiology and immunity, yet the mechanisms linking physical activity to disease protection remain incompletely defined. Emerging evidence indicates that exercise remodels the gut microbiome, producing compositional and metabolic adaptations that can regulate immune function. In this Review, we discuss how … Read more

Mitochondrial Complex II in the regulation of immunopathology. Akira Yamamoto

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Trends Immunol. 2026 Aug 18:S1471-4906(26)00192-4. doi: 10.1016/j.it.2026.07.013. Online ahead of print. ABSTRACT Mitochondrial complex II, succinate dehydrogenase (SDH), links the tricarboxylic acid cycle to the electron transport chain by oxidizing succinate to fumarate and reducing ubiquinone. This unusual position gives Complex II control over bioenergetics, redox state, succinate signaling, and chromatin regulation. In immune cells, … Read more

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