inmunoadmin

Systemic MIF facilitates chronic lymphocytic leukemia development independent of its cellular source​Viktoria Kohlhas on 29 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 29:qiaf170. doi: 10.1093/jleuko/qiaf170. Online ahead of print. ABSTRACT Macrophage migration inhibitory factor (MIF) is broadly produced by various cell types, particularly immune cells, and functions as a key modulator of innate and adaptive immunity. Increasing evidence has linked MIF to the pathogenesis of both solid tumors and hematologic malignancies, including … Read more

Galectin-3 promotes sialyl Lewis X epitope biosynthesis in monocytes​Jennifer Judge on 28 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 28:qiaf168. doi: 10.1093/jleuko/qiaf168. Online ahead of print. ABSTRACT Monocytes play a fundamental role in the inflammatory response to diverse stimuli. A critical early step in the initiation of this response is the recruitment of monocytes from the bloodstream to sites of tissue injury. This migration is tightly regulated at the … Read more

IgA and IgM-enriched Immunoglobulins in Primary Immunodeficiencies: a Pilot Study

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J Clin Immunol. 2025 Nov 28. doi: 10.1007/s10875-025-01966-z. Online ahead of print. ABSTRACT PURPOSE: Despite well-conducted replacement therapy with polyvalent immunoglobulins (IgRT), some patients with primary immunodeficiencies (PID) continue to experience recurrent or chronic infections. IgA and IgM, essential for mucosal and complement-mediated immunity, are absent or minimal in standard immunoglobulin products. The aim of … Read more

Exosomes in Autoimmunity: Mediators of Autoantigen Presentation and Targets for Therapeutic Intervention in Autoimmune Diseases

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J Clin Immunol. 2025 Nov 28. doi: 10.1007/s10875-025-01965-0. Online ahead of print. ABSTRACT Exosomes, as integral mediators of cellular communication, have emerged as crucial players in the pathogenesis and potential treatment of autoimmune diseases. This review explores the dual role of exosomes in mediating autoantigen presentation and their impact on immune dysregulation. Exosomes, by virtue … Read more

Get with the program: regulation of T cell death. Timothy Patton

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Trends Immunol. 2025 Nov 25:S1471-4906(25)00272-8. doi: 10.1016/j.it.2025.10.015. Online ahead of print. ABSTRACT Programmed cell death (PCD) encompasses several tightly regulated molecular signalling pathways, leading to the controlled destruction of cells. Apoptosis is a non-immunogenic form of cell death that regulates homeostasis to cell stressors. In contrast, lytic forms of cell death – necroptosis, pyroptosis, and … Read more

Pyroptosis modulates multiple immune cell populations in targeted therapy-treated melanoma

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Cancer Immunol Res. 2025 Nov 26. doi: 10.1158/2326-6066.CIR-25-0444. Online ahead of print. ABSTRACT Treatment of melanoma with BRAF inhibitors plus MEK inhibitors (BRAFi + MEKi) stimulates an intratumoral immune response, in part through pyroptosis mediated by the pore-forming protein gasdermin E (GSDME/Gsdme). How GSDME mediates effects on tumoral immunity is not well characterized. Using single-cell … Read more

From discovery to complexity: the evolving role of age-associated B cells in immunity, aging, and disease

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J Immunol. 2025 Nov 1;214(11):2809-2811. doi: 10.1093/jimmun/vkaf232. ABSTRACT This Pillars of Immunology article is a commentary on “A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice,” a pivotal article written by Hao Y, O’Neill P, Naradikian MS, Scholz JL, and Cancro MP, and published in Blood in 2011 (PMID: 21562046; PMCID: PMC3152496). … Read more

TAP-I Deficiency Presenting With Chronic Granulomatous Rubella Virus-Driven Cutaneous Ulceration: A Case Report and Scoping Literature Review

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J Clin Immunol. 2025 Nov 27. doi: 10.1007/s10875-025-01919-6. Online ahead of print. ABSTRACT Autosomal recessive mutations in TAP1, TAP2, TAPBP, or B2M, are associated with major histocompatibility complex (MHC) class I deficiency. Individuals may present with granulomatous skin ulceration, but the underlying antigenic triggers remain largely unknown. We identified TAP1 deficiency in a 32-year-old female … Read more

Aging changes the mechanism that underlies JAK2 modulation of neutrophil function

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J Immunol. 2025 Nov 25:vkaf323. doi: 10.1093/jimmun/vkaf323. Online ahead of print. ABSTRACT Janus kinase 2 (JAK2) has been linked to various neutrophil functions, but the intracellular mechanisms underlying its modulation are unknown. Neutrophils are essential cells for host defense. Neutrophil effector functions include migration, neutrophil extracellular trap production (NETosis), reactive oxygen species (ROS) production, and … Read more

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