inmunoadmin

MERTK inhibition cooperates with immunomodulatory cyclophosphamide to induce CXCL9⁺ monocyte-macrophage programming and durable antitumor immunity in triple negative breast cancer

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Cancer Immunol Res. 2026 Aug 17. doi: 10.1158/2326-6066.CIR-26-0278. Online ahead of print. ABSTRACT Triple-negative breast cancer (TNBC) has high rates of recurrence despite chemotherapy and immune checkpoint blockade (ICB). Tumor-associated macrophages (TAMs) can either suppress or support antitumor immunity, but the mechanisms governing these states and therapeutic targets remain unclear. Here, integrating public scRNAseq datasets … Read more

Elevated IL-10 is Linked With the Expansion of T-bethighCD21low B Cells in Patients With Common Variable Immunodeficiency

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J Clin Immunol. 2026 Aug 15;46(1):83. doi: 10.1007/s10875-026-02058-2. ABSTRACT Common variable immunodeficiency (CVID) is frequently complicated by autoimmune and inflammatory manifestations associated with profound immune dysregulation (CVIDc), including expansion of T-bethighCD21low B cells (CD21low B cells). Elevated serum IL-10 levels have repeatedly been reported in CVIDc, yet their relationship to CD21low B-cell differentiation remains unclear. … Read more

Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B-specific CD4+ T cell responses

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J Immunol. 2026 Aug 4;215(8):vkag152. doi: 10.1093/jimmun/vkag152. ABSTRACT The gastrointestinal pathogen Clostridioides difficile is a major burden for health systems due to high rates of recurrence. C. difficile pathogenesis is mediated by two virulence factors, toxin A (TcdA) and toxin B (TcdB). Antibodies specific for TcdA and TcdB are correlated with protection from symptomatic recurrence; … Read more

Multimodal and fair artificial intelligence in paediatric rheumatology: challenges and opportunities for a holistic and equitable future

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Curr Opin Immunol. 2026 Aug 14;102:102835. doi: 10.1016/j.coi.2026.102835. Online ahead of print. ABSTRACT Multimodal artificial intelligence (AI) is an emerging domain comprising a set of tools with potential clinical relevance in paediatric rheumatology, a field characterised by rare, heterogeneous diseases and diagnostic delays. This narrative review synthesises current evidence on how multimodal and fair AI … Read more

One lipid to imprint them all?. Nicolas Cénac

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Trends Immunol. 2026 Aug 14:S1471-4906(26)00188-2. doi: 10.1016/j.it.2026.07.009. Online ahead of print. ABSTRACT A recent report by Fan et al. identifies trans-vaccenic acid, a maternal diet-derived lipid transferred through breast milk, as a key regulator of neonatal T-cell development. Beyond identifying a single bioactive metabolite, this study positions breast milk as a source of developmental signals … Read more

The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease​Carlos Silvestre-Roig on 14 de August de 2026 at 10:00

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J Leukoc Biol. 2026 Aug 14:qiag113. doi: 10.1093/jleuko/qiag113. Online ahead of print. ABSTRACT Myeloid cells orchestrate vascular inflammation through transcriptional programs that control their maturation, effector function, and survival. While lineage-determining transcription factors establish myeloid identity, our understanding of the transcriptional regulation of myeloid cell behavior in chronic inflammatory contexts remains limited. Nuclear factor-Y (NF-Y) … Read more

TIM3 blockade with hypomethylating therapy restores NK-cell and cytotoxic CD4+ T-cell activity in patients with AML or MDS

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Cancer Immunol Res. 2026 Aug 14. doi: 10.1158/2326-6066.CIR-26-0160. Online ahead of print. ABSTRACT Occasional complete responses to immune checkpoint inhibitor therapy demonstrate that acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) can be immune-sensitive when appropriately targeted. Here, we analyzed AML/MDS patients (n=14) treated with the anti-TIM3 sabatolimab and the hypomethylating agent decitabine in a … Read more

Deficiency in circulating T cells in four core genotypes mice with Sry translocation

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J Immunol. 2026 Aug 4;215(8):vkag207. doi: 10.1093/jimmun/vkag207. ABSTRACT Sex differences exist in the immune responses to infections and in the prevalence and severity of autoimmune and allergic diseases. These sex differences may be caused by sex hormones and/or variable inactivation of X chromosome genes. The 4 core genotypes mice allow for distinction between the effects … Read more

Efferent ductule epithelium orchestrates reproductive immune homeostasis under inflammatory stress. L Vinay

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Mucosal Immunol. 2026 Aug 13:100400. doi: 10.1016/j.mucimm.2026.100400. Online ahead of print. ABSTRACT Immune dysregulation is increasingly recognized as a key contributor to male infertility, yet the role of the efferent ductules in reproductive immune homeostasis remains unexplored. Located between the immune-privileged testis and the epididymis, efferent ductules are essential for male fertility by reabsorbing over … Read more

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