inmunoadmin Trends Immunol. 2026 Aug 13:S1471-4906(26)00186-9. doi: 10.1016/j.it.2026.07.007. Online ahead of print. ABSTRACT Natural killer (NK) cells are effectors of innate antitumor immunity, yet their therapeutic potential in solid tumors remains largely unrealized. Breast cancer exemplifies this paradox: NK cells are present in circulation and detectable within tumors, but their cytotoxic activity is limited. Recent advances … Read more
Semin Immunol. 2026 Aug 13;83:102054. doi: 10.1016/j.smim.2026.102054. Online ahead of print. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health challenge and the leading cause of death from a single infectious agent. Despite diagnostic and therapeutic advances, the COVID-19 pandemic reversed progress in TB control, with a notable rise in incidence … Read more
J Immunol. 2026 Aug 4;215(8):vkag220. doi: 10.1093/jimmun/vkag220. ABSTRACT Little is known about the role of semaphorin 3E (Sema3E) in B cell responses and immunoglobulin regulation. Our recent data indicate that Sema3e knockout mice have significantly higher serum levels of total and allergen-specific IgE in allergic asthma, suggesting Sema3E’s crucial role in modulating the humoral response. … Read more
J Immunol. 2026 Aug 4;215(8):vkag219. doi: 10.1093/jimmun/vkag219. ABSTRACT Systemic sclerosis (SSc) is an autoimmune condition affecting several organs. It is identified by thickening of the dermis, connective tissue affected by collagen accumulation, and vascular injuries that induce hypoxia. The present study aimed to determine whether extracellular vesicles (EVs) from adipose-derived stem cells (ADSCs) attenuated bleomycin-induced … Read more
J Immunol. 2026 Aug 4;215(8):vkag228. doi: 10.1093/jimmun/vkag228. ABSTRACT Sepsis-induced cardiac dysfunction is a primary contributor to mortality, and microRNAs (miRNAs) are recognized as crucial mediators in sepsis pathogenesis. This study aims to identify the key regulatory miRNAs involved in cardiac dysfunction stemming from sepsis. We developed a rat model of sepsis using cecal ligation and … Read more
J Immunol. 2026 Aug 4;215(8):vkag198. doi: 10.1093/jimmun/vkag198. ABSTRACT Type 1 conventional dendritic cells (cDC1s) are important for generating and sustaining antitumor immunity. Accordingly, the abundance of cDC1s in human tumors correlates with improved outcomes in cancer. Capitalizing on this role, we previously demonstrated that vaccination with murine cDC1s, generated in culture from bone marrow cells … Read more
Cancer Immunol Res. 2026 Aug 13. doi: 10.1158/2326-6066.CIR-26-0365. Online ahead of print. ABSTRACT Endogenous retrotransposable elements (EREs) can modulate immune responses. We explored ERE transcription in relation to response to immune checkpoint inhibition in advanced solid tumors. ERE expression was measured in pre and on-treatment samples from patients treated in a clinical trial with pembrolizumab. … Read more
Cancer Immunol Res. 2026 Aug 13. doi: 10.1158/2326-6066.CIR-26-0126. Online ahead of print. ABSTRACT Alterations in peripheral immunity may contribute to fatal prostate cancer and the excessive disease burden among African American (AA) men. Thus, we investigated peripheral immunity in prostate cancer patients in association with disease outcome and AA descent. We performed single-cell RNA and … Read more
J Immunol. 2026 Aug 4;215(8):vkag212. doi: 10.1093/jimmun/vkag212. ABSTRACT Mucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR) that recognizes bacterial-derived antigens presented on MR1. Upon TCR triggering, MAIT cells respond rapidly, producing a range of effector molecules which facilitate host-protective responses in the context of microbial infections. In contrast, MAIT cell responses … Read more
J Immunol. 2026 Aug 4;215(8):vkag200. doi: 10.1093/jimmun/vkag200. ABSTRACT Lysosomes drive antigen proteolysis and peptide loading for major histocompatibility complex class II (MHCII) presentation in antigen-presenting cells (APCs), enabling activation of peptide-specific CD4+ T helper cells (CD4+ Th cells). Tight regulation of endocytic trafficking, protease activity, and peptide editing is required to generate stable peptide-MHCII complexes … Read more
