inmunoadmin

Immunogenicity‐Guided Design of an Acinetobacter baumanii Vaccine. [[{“value”:”Chenghua Zhu, Shuaiyuan Liang, Ning Yang, Shan Li, Jianpeng Xue, Runlu Zhou, Xiuwen Hong, Sixi Chen, Nan Gao, Qiang Du, Jianling Huang, Ganzhu Feng, Xingran Du”}]]

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Schematic diagram of DCpep-NM-PLGA-rOmpW preparation and its immunoprotective effects on acute lethal pneumonia. This study developed a biomimetic nanovaccine (DCpep-NM-PLGA-rOmpW) against A. baumannii. The nanoparticle-delivered multiepitope vaccine induced robust Th1/Th17 and antibody responses, demonstrating significant protection in a lethal pneumonia model. ABSTRACT The development of vaccines represents a promising and safe strategy to combat multidrug-resistant … Read more

Immunological Impact of Oncolytic Adenoviruses On Cancer Therapy: Clinical Insights. [[{“value”:”Reza Nadafi, Wenliang Dong, Victor W. van Beusechem”}]]

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Conditionally replicating oncolytic adenoviruses (OAds) mediate cancer cell destruction while triggering robust immune responses. Clinical data reveal their ability to remodel the tumor microenvironment and enhance responsiveness when combined with other therapies. This review highlights immune-modulating effects of OAds in patients, with a focus on therapeutic implications and combination strategies. ABSTRACT Oncolytic immunotherapy, particularly using … Read more

Aging and Viral Evolution Impair Immunity Against Dominant Pan‐Coronavirus‐Reactive T Cell Epitope. [[{“value”:”Lucie Loyal, Karsten Jürchott, Ulf Reimer, Lil Meyer‐Arndt, Larissa Henze, Norbert Mages, Jak Kostrzanowski, Bernhard Reus, Maike Mangold, Beate Kruse, Manuela Dingeldey, Birgit Sawitzki, Janine Michel, Marica Grossegesse, Karsten Schnatbaum, Holger Wenschuh, Andreas Nitsche, Nils Lachmann, Bernd Timmermann, Claudia Giesecke‐Thiel, Julian Braun, Florian Kern, Andreas Thiel”}]]

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The immunodominant pan-coronavirus epitope iCope spans amino acids 816–830 within the fusion domain of the SARS-CoV-2 spike glycoprotein. This region exhibits a comparatively low mutation rate, especially when contrasted with the receptor-binding domain (RBD). Antigen-specific T cell responses against iCope are detectable even in unexposed individuals, are modestly enhanced following SARS-CoV-2 infection, and are robustly … Read more

Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells. Samuel Alvarez-Arguedas

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Mucosal Immunol. 2025 Jul 26:S1933-0219(25)00077-7. doi: 10.1016/j.mucimm.2025.07.006. Online ahead of print. ABSTRACT The nasal, oropharyngeal, and bronchial mucosa are primary contact points for airborne pathogens like Mycobacterium tuberculosis (Mtb), SARS-CoV-2, and influenza virus. While mucosal surfaces can function as both entry points and barriers to infection, mucosa-associated lymphoid tissues (MALT) facilitate early immune responses to … Read more

The recall of antigen-specific antibody-secreting cells in Solea senegalensis gives clues on the secondary immune response in flatfish

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J Immunol. 2025 Jul 25:vkaf159. doi: 10.1093/jimmun/vkaf159. Online ahead of print. ABSTRACT In this study, monoclonal antibodies (mAbs) specific for sole immunoglobulin M (IgM) were generated, which allowed us to evaluate the kinetics of IgM+ B cell responses, assess the recruitment of these cells to the peritoneum following vaccination, and compare the dynamics of antigen-specific … Read more

Clonally expanded IgG, but not IgA, antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections

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J Immunol. 2025 Jul 26:vkaf144. doi: 10.1093/jimmun/vkaf144. Online ahead of print. ABSTRACT Infection with influenza virus remains a significant global health concern due to its ability to acquire mutations at key antigenic sites to escape antibody recognition. While germinal center (GC) and memory B cells have been well studied following influenza infection, the clonal dynamics … Read more

The MAIT cell response to controlled oral enterotoxigenic E. coli challenge

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J Immunol. 2025 Jul 26:vkaf143. doi: 10.1093/jimmun/vkaf143. Online ahead of print. ABSTRACT Mucosal-associated invariant T (MAIT) cells recognize conserved microbial antigens presented by the non-polymorphic MR1 molecules and play important roles in barrier immunity. Enterotoxigenic E. coli (ETEC) is a major cause of diarrheal disease in children in lower-income countries and among travelers. Here we … Read more

Machine Learning Reassessment of Serum Immune Factors Shows No Unique Immune Profiles Linked to Disease Outcomes in SARS‐CoV‐2‐infected Patients at Hospital Admittance. [[{“value”:”Stefania Rossi, Imerio Capone, Enrico Cabri, Anna Giabelli, Ilaria Rossoni, Giulia Romagnoli, Stefano M. Santini, Cinzia Marcantonio, Roberto Giuseppetti, Umbertina Villano, Roberto Bruni, Anna R. Ciccaglione, Federica Frasca, Alessandra d’Auria, Ginevra Bugani, Gabriella d’Ettorre, Guido Antonelli, Carolina Scagnolari, Maddalena Fratelli, Lucia Gabriele”}]]

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Machine learning analysis of serum immune factors clustered SARS-CoV-2 patients into moderate (balanced-immune-modulation [BIM]) and severe groups; the latter composed of two distinct and opposite immune patterns (down-immune-modulation [DIM] and up-immune-modulation [UIM]). DIM/UIM and BIM clusters show different clinical, laboratory and immune parameters including T and B lymphocytes. ABSTRACT The complex pathophysiology of severe acute … Read more

Discordant Restoration of TCR Expression and Function by CD247 Somatic Reversions

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J Clin Immunol. 2025 Jul 25;45(1):116. doi: 10.1007/s10875-025-01908-9. ABSTRACT BACKGROUND: The CD247 chain of the T-cell receptor (TCR) is essential for normal T cell development and function. Reported CD247-deficient patients showed severe immunodeficiency despite the presence of two populations of peripheral T cells, most with low TCR levels carrying the germline variant and a few … Read more

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