inmunoadmin

Diverse IL-9-secreting T helper cells direct responses in the allergic lung. Kaitlyn G Jackson

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Semin Immunol. 2026 Jan 14;81:102014. doi: 10.1016/j.smim.2026.102014. Online ahead of print. ABSTRACT IL-9 promotes airway hyperresponsiveness, eosinophilia, mast cell expansion, and antibody-mediated inflammation through interactions with mast cells, eosinophils, B cells, and airway and lung macrophages in models of allergic airway disease. IL-9 has increasingly been linked to asthma severity in patients. Early studies primarily … Read more

Elderly-onset rheumatoid arthritis as a distinct entity: mechanisms, manifestations, and treatment

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Curr Opin Immunol. 2026 Jan 13;99:102721. doi: 10.1016/j.coi.2025.102721. Online ahead of print. ABSTRACT Elderly-onset rheumatoid arthritis (EORA), defined as onset at ≥60 years, is a clinically distinct and increasingly prevalent subset of rheumatoid arthritis (RA). This review synthesizes evidence that EORA is not merely late-onset RA but a pathogenically unique entity, driven by immune aging, … Read more

A critical look at animal and cellular models in autoinflammatory diseases

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Curr Opin Immunol. 2026 Jan 13;99:102719. doi: 10.1016/j.coi.2025.102719. Online ahead of print. ABSTRACT Autoinflammatory diseases (AIDs) comprise a diverse group of conditions arising from dysregulated immune control due to congenital or acquired genetic abnormalities in innate immune pathways, and patients typically require lifelong treatment. Owing to their rarity, access to patient samples is limited, making … Read more

New autoantibodies in Sjögren’s disease

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Curr Opin Immunol. 2026 Jan 13;99:102722. doi: 10.1016/j.coi.2025.102722. Online ahead of print. ABSTRACT Primary Sjögren’s disease (SjD) is a systemic autoimmune disorder where diagnosis relies on the presence of Ro/SS-A and La/SS-B autoantibodies. However, approximately one-third of SjD patients are seronegative, often requiring an invasive minor salivary gland biopsy, which can lead to significant diagnostic … Read more

Targeting Tumor-Draining Lymph Nodes to Improve the Therapeutic Potential of Oncolytic Viruses

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Cancer Immunol Res. 2026 Jan 14:OF1-OF2. doi: 10.1158/2326-6066.CIR-25-1596. Online ahead of print. ABSTRACT Oncolytic viruses (OV) are thought to mediate antitumor activity by killing tumor cells and inducing antitumor immunity, but how this happens is not well understood. In this issue, Ludwig and colleagues show that PVSRIPO, an oncolytic poliovirus being developed for glioblastoma, may … Read more

Immunity at the edge: Cell-intrinsic roles for intestinal epithelial cells in host immunity​Thomas Charron on 14 de January de 2026 at 11:00

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J Leukoc Biol. 2026 Jan 14:qiag010. doi: 10.1093/jleuko/qiag010. Online ahead of print. ABSTRACT As the barrier between the contents of the intestines and the rest of the body, intestinal epithelial cells (IEC) occupy a crucial niche for the health of the organism. They are responsible for nutrient absorption and transfer, barrier maintenance, and interactions with … Read more

Eosinophils: Pathological Mechanisms and Novel Targeted Therapeutic Strategies Across Multiple Disease Spectrums​Yuan Chen on 14 de January de 2026 at 11:00

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J Leukoc Biol. 2026 Jan 14:qiag009. doi: 10.1093/jleuko/qiag009. Online ahead of print. ABSTRACT Eosinophils are a type of white blood cell belonging to the granulocyte family. Their cytoplasm contains eosinophilic granules that hold various biologically active substances. They perform diverse functions, participating in inflammatory responses, immune defense, and tissue repair. Eosinophils are implicated in the … Read more

Taking “Multiple Shots on Goal” with an Armed Invariant NK Cell Approach

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Cancer Immunol Res. 2026 Jan 13:OF1-OF2. doi: 10.1158/2326-6066.CIR-25-1344. Online ahead of print. ABSTRACT Adoptive T-cell therapies have shown limited efficacy against solid tumors, so new approaches are required. In this issue, Chantzoura and colleagues describe MiNK-215, a novel allogeneic fibroblast activation protein-targeting chimeric antigen receptor invariant NK T-cell therapy engineered to secrete IL15. They show … Read more

The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells. [[{“value”:”Maria Romero, Amanda Virtue, Kate Miller, Andrew Gelsomini, Dhananjay Suresh, Sophie LaPointe, Suresh Pallikkuth, Daniela Frasca”}]]

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The increased lactate secretion by B cells from people with obesity and aging is a stimulus for pathogenic autoimmune anti-dsDNA antibodies. The effects of lactate are mediated by phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and inhibited by a neutralizing antibody that blocks the lactate transporter SLC5A12, responsible for lactate uptake and activation … Read more

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