A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors
Cancer Immunol Res. 2026 Mar 4;14(3):373. doi: 10.1158/2326-6066.CIR-14-3-WWR. NO ABSTRACT PMID:41777151 | DOI:10.1158/2326-6066.CIR-14-3-WWR
inmunoadmin
Two Cases of CLIPPERS-like Syndrome Sharing a Hypomorphic UNC13D Variant
J Clin Immunol. 2026 Mar 4;46(1):23. doi: 10.1007/s10875-026-01988-1. NO ABSTRACT PMID:41781714 | DOI:10.1007/s10875-026-01988-1
Endothelial dysfunction in APS: advancing pathophysiological understanding to improve management
Curr Opin Immunol. 2026 Mar 2;100:102745. doi: 10.1016/j.coi.2026.102745. Online ahead of print. ABSTRACT Endothelial dysfunction (ED) is a hallmark of antiphospholipid syndrome (APS) driven by chronic antiphospholipid antibody (aPL) exposure. Beyond acute thrombotic events, ED contributes to atherosclerosis, vascular remodelling, stenosis and multi-organ manifestations, positioning the endothelium as a putative target for disease monitoring and … Read more
Decidual immune activation by extravillous trophoblasts drives maternal-fetal tolerance and immunity. Tamara Tilburgs
Trends Immunol. 2026 Mar 2:S1471-4906(26)00014-1. doi: 10.1016/j.it.2026.01.011. Online ahead of print. ABSTRACT During pregnancy, complex interactions of maternal immune cells and fetal extravillous trophoblasts (EVTs) orchestrate placentation, immune tolerance, and immune defense. This forum article highlights important discoveries and outstanding questions on how the activation of decidual natural killer and T cells, through recognition of … Read more
Unraveling BCR Repertoire Diversity and its Impact on Glucocorticoid Therapy in Pediatric Idiopathic Nephrotic Syndrome
J Clin Immunol. 2026 Mar 2. doi: 10.1007/s10875-026-01994-3. Online ahead of print. ABSTRACT AIM: Idiopathic nephrotic syndrome (INS) is the most common glomerular disease in children, but its underlying mechanisms remain unclear. Although glucocorticoids (GC) are the first-line treatment, approximately 10% of INS cases are steroid-resistant (SRNS), and 50% may progress to refractory nephrotic syndrome … Read more
38‐Marker Full‐Spectrum Flow Cytometry Panel for the Comprehensive Profiling of γδ T Cells in Human Blood and Lymphoid Tissues. [[{“value”:”Mohamed Hamed, Daniela Moreno‐Vicencio, Daniel Arsovski, Mustafa Farhat, Rosie Sanders, Ellen Mann, Annabelle Bennett, Priyanka Chevour, Martin S. Davey”}]]
This is an update to the Guidelines for the Use of Flow Cytometry and Cell Sorting in Immunological Studies (Third Edition), Chapter 12C, by Cossarizza et al. A 38-marker full-spectrum flow cytometry panel enabling high-resolution profiling of human γδ T cells across blood and lymphoid tissues, including robust identification of rare, tissue-adapted subsets.
Inhaled Acinetobacter lwoffii exposure promotes lung PD-L1+ neutrophils and dampens viral-induced type 2 immunity. Kunyuan Tian
Mucosal Immunol. 2026 Feb 27:S1933-0219(26)00024-3. doi: 10.1016/j.mucimm.2026.02.007. Online ahead of print. NO ABSTRACT PMID:41765103 | DOI:10.1016/j.mucimm.2026.02.007
Toxoplasma gondii effector MAF1 blocks mouse AIM2 inflammasome activation by inhibiting mtDNA release
J Immunol. 2026 Feb 9;215(2):vkaf360. doi: 10.1093/jimmun/vkaf360. ABSTRACT Toxoplasma gondii is an obligate intracellular pathogen that can infect most nucleated cell types in rodents and humans. Parasite infection is regulated by inflammasome activation, downstream of Toll-like receptors (TLRs) priming, and interferon γ (IFN-γ)-mediated activation of immunity inducible GTPases. In vivo, the activation of these pathways … Read more
A comparison of amphibian (Xenopus laevis) peritoneal- and bone marrow-derived mast cells
J Immunol. 2026 Feb 9;215(2):vkaf363. doi: 10.1093/jimmun/vkaf363. ABSTRACT Mast cells are tissue-resident granulocytes that are often viewed through a negative lens due to their roles in allergies and hypersensitivity. While central to these conditions, mast cells have broader roles in vertebrate immune systems that are often overlooked. Whereas most mast cell research to date has … Read more
MLL1 directs gut-associated antibody responses to helminth and bacterial infections
J Immunol. 2026 Feb 9;215(2):vkaf358. doi: 10.1093/jimmun/vkaf358. ABSTRACT Soil-transmitted helminths are one of the most common infections globally, yet how to promote effective gut-associated humoral responses is not well understood. We identify the histone methyltransferase MLL1 as a key target to promote IgA-driven responses. Mll1 was increased in germinal center B cells in gut-associated lymphoid … Read more