inmunoadmin Cancer Immunol Res. 2025 Apr 28. doi: 10.1158/2326-6066.CIR-24-0852. Online ahead of print. ABSTRACT Adaptive Natural Killer (aNK) cells have emerged as a subset of NK cells with memory-like properties and specific cytotoxicity, offering promising therapeutic potential in cancer immunotherapy. In this study, we explored the role of aNK cells in high-grade serous ovarian cancer (HGSOC), … Read more
J Clin Immunol. 2025 Apr 28;45(1):89. doi: 10.1007/s10875-025-01882-2. ABSTRACT Monogenic defects that impair the control of inflammation and tolerance lead to profound immune dysregulation, including autoimmunity and atopy. Studying these disorders reveals important molecular and cellular factors that regulate human immune homeostasis and identifies potential precision medicine targets. Here, we provide a detailed immunological assessment … Read more
Mucosal Immunol. 2025 Apr 25:S1933-0219(25)00043-1. doi: 10.1016/j.mucimm.2025.04.005. Online ahead of print. ABSTRACT Pregnancies rely upon the balance between fetal and maternal immune systems. Employing imaging mass cytometry, this study creates a spatial map landscape to unravel the cellular dynamics within the placental villi (PV). Consistent with previous data we report structural remodeling in PV, highlighted … Read more
Semin Immunol. 2025 Apr 26;78:101957. doi: 10.1016/j.smim.2025.101957. Online ahead of print. ABSTRACT In response to stress stimuli, cells have evolved various mechanisms to integrate internal and external signals to achieve dynamic homeostasis. Lysine acetyltransferase (KATs) and deacetyltransferase (KDACs) are the key modulators of epigenetic modifications, enabling cells to modulate cellular responses through the acetylation and … Read more
J Immunol. 2025 Apr 25:vkaf028. doi: 10.1093/jimmun/vkaf028. Online ahead of print. ABSTRACT Mannose-binding lectin (MBL) is a vital and versatile component of innate immunity, which plays an essential role in host defense. In mammals, MBL performs multiple functions, including pattern recognition, complement activation, and phagocytosis. Previous studies revealed that OnMBL can promote the opsonophagocytosis of … Read more
J Immunol. 2025 Apr 25:vkae058. doi: 10.1093/jimmun/vkae058. Online ahead of print. ABSTRACT The capacity of Mycobacterium tuberculosis (Mtb) to establish long-term survival is attributed to its ability to subvert host defense mechanisms, especially macrophages. Although Mtb lipids are believed to play a role in this host-pathogen crosstalk, how mycobacterial lipids drive this complex interaction is … Read more
J Immunol. 2025 Apr 25:vkaf074. doi: 10.1093/jimmun/vkaf074. Online ahead of print. ABSTRACT T cell-independent type 2 antigens (TI-2 Ags), such as pneumococcal polysaccharides, elicit weak immunoglobulin G (IgG) responses and are refractive to boosting. Overcoming this challenge is critical for improving vaccines. Previously, we demonstrated a lipid-based adjuvant composed of monophosphoryl lipid A, synthetic cord … Read more
J Immunol. 2025 Apr 25:vkaf057. doi: 10.1093/jimmun/vkaf057. Online ahead of print. ABSTRACT Human metapneumovirus (HMPV) is a leading cause of lower respiratory tract infection in children accounting for 7% of acute care visits and hospitalizations. In particular, neonates and infants have worse outcomes with HMPV infection. The neonatal immune system is regulated to favor anti-inflammatory … Read more
Mucosal Immunol. 2025 Apr 23:S1933-0219(25)00045-5. doi: 10.1016/j.mucimm.2025.04.007. Online ahead of print. ABSTRACT Severe respiratory syncytial virus (RSV) infection during infancy is associated with a 2 to 4-fold increased risk for the development of wheezing and asthma. Recent studies have implicated microbiome changes, either within the lung or gut, during early life can also affect the … Read more
Multiple immunizations of mice with Plasmodium berghei radiation-attenuated sporozoites (Pb RAS) induce durable protective immunity, provided that 1° sporozoite (spz) challenge occurs early or within 10 months following the most recent RAS boost immunization. Delaying 1° challenge results in parasitemia. Pb RAS develops partially into early liver stages, is unable to progress to blood-stage parasites, … Read more
