inmunoadmin

Differential Induction of Endoplasmic Reticulum Stress Signaling by Antibody Isotypes: Implications for Plasma Cell Differentiation. [[{“value”:”Kunie Obayashi, Tomomitsu Doi, Kazuhiro Sumida, Motoyoshi Endo”}]]

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IgE induces stronger ER stress than IgG1 due to its constant region, particularly the Cε3 domain, which binds BiP more efficiently. Genetic and structural analyses confirmed IgE’s higher BiP-binding capacity. ER stress, driven by IRE1-XBP1 signaling, regulates plasma cell differentiation, suggesting IgE-specific mechanisms in immune responses.

An antigen-less pro-vaccine for treating autoimmunity

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J Immunol. 2025 Apr 24:vkaf068. doi: 10.1093/jimmun/vkaf068. Online ahead of print. ABSTRACT We have designed the first antigen-less pro-vaccine, named 8206, for treating autoimmune diseases. Composed of dexamethasone, rapamycin, and R848 at a mass ratio of 8:20:6, 8206 is a complete tolerogenic adjuvant that acts systemically to form an active vaccine in situ with endogenous … Read more

Depression-like behavior is associated with changes in the meningeal lymphatic vasculature and meningeal B cells in a murine lupus model​Alexandra Olate-Briones on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 23;117(4):qiaf016. doi: 10.1093/jleuko/qiaf016. ABSTRACT Meningeal lymphatic vasculature (mLV) comprises a network of vessels responsible for draining immune cells and fluid from the central nervous system (CNS) into the deep cervical lymph nodes. While changes in mLV function have been implicated in several neurodegenerative disorders, its role in autoimmune diseases is … Read more

Protective function of ex vivo-expanded CD8 T cells in a mouse model of adoptive therapy for cytomegalovirus infection depends on integrin beta 1 but not CXCR3, CTLA4, or PD-1 expression​Xiaokun Liu on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 23;117(4):qiae256. doi: 10.1093/jleuko/qiae256. ABSTRACT The adoptive transfer of virus-specific T cells (VSTs) represents a therapeutic option for viral infection treatment in immunocompromised patients. Before administration, ex vivo culture enables VST expansion. However, it is unclear how ex vivo expansion affects the circulation, homing, and intra-tissue migration of administered VSTs. We … Read more

Different behavior of NK cells isolated from healthy women and women with recurrent spontaneous abortion after treatment with human amniotic epithelial cells​Fatemeh Rezayat on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 23;117(4):qiaf020. doi: 10.1093/jleuko/qiaf020. ABSTRACT Maternal immunotolerance during pregnancy is heavily dependent on the critical properties of human amniotic epithelial cells (hAECs). Recurrent spontaneous abortion (RSA) is one of the most common diseases in women and is caused by feto-maternal immunotolerance disruption. The objective of this study is to investigate how … Read more

Regulation and therapeutic potential of NLRP3 inflammasome in intestinal diseases​Wenxue Li on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 23;117(4):qiaf014. doi: 10.1093/jleuko/qiaf014. ABSTRACT The NOD-like receptor family, particularly the protein 3 that contains the pyrin domain (NLRP3), is an intracellular sensing protein complex responsible for detecting patterns associated with pathogens and injuries. NLRP3 plays a crucial role in the innate immune response. Currently, a wide range of research has … Read more

The release of NETs during SFTSV infection downregulates the specific inflammatory factors that lead to liver and spleen damage​Xuewen Ji on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 25:qiaf053. doi: 10.1093/jleuko/qiaf053. Online ahead of print. ABSTRACT Severe fever with thrombocytopenia syndrome is a life-threatening condition that has been the focus of attention in recent years. It is primarily caused by uncontrolled replication of a novel Bunyavirus and an intense pro-inflammatory response. NETosis is a form of cell death … Read more

Presence of LILRB4 SNP rs1048801 modulates Acute Myeloid Leukemia progression and inhibits CD4+ T cells proliferation​Zhiyong Zhou on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 25:qiaf052. doi: 10.1093/jleuko/qiaf052. Online ahead of print. ABSTRACT Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), an emerging immune checkpoint molecule, exhibits therapeutic potential in acute myeloid leukemia (AML). While single nucleotide polymorphisms (SNPs) of immune checkpoint genes have been extensively investigated in AML, the association between LILRB4 genetic polymorphisms … Read more

Immune therapies in coeliac disease and food allergies: Advances, challenges, and opportunities. Dianne E Campbell

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Semin Immunol. 2025 Apr 23;78:101960. doi: 10.1016/j.smim.2025.101960. Online ahead of print. ABSTRACT Coeliac disease and food allergy management primarily relies on the strict avoidance of dietary antigens. This approach is challenging to maintain in real-world settings and in food allergy carries the risk of life-threatening anaphylaxis. Despite their distinct pathogenesis, both disorders are driven by … Read more

What’s Atypical about Human B cells after Allogeneic Stem Cell Transplantation?​Sonali J Bracken on 24 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 24:qiaf048. doi: 10.1093/jleuko/qiaf048. Online ahead of print. ABSTRACT Atypical B cells or age-associated B cells (ABCs) represent an alternative lineage of memory B cells. Emerging evidence suggests that context influences the apparent functional heterogeneity of ABCs. While data support a protective role for ABCs in the setting of infection, multiple … Read more

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