inmunoadmin

An era of immunological discoveries heralded by molecular biology. Amy Kenter

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Trends Immunol. 2025 Apr 15:S1471-4906(25)00077-8. doi: 10.1016/j.it.2025.03.003. Online ahead of print. ABSTRACT The Molecular Mechanisms of Immune Cell Development and Function (MMICDF) meeting sponsored by the Federation of American Societies of Experimental Biology (FASEB) occupies a special niche because of its focus on the molecular mechanisms that underpin immunological processes. This biennial meeting with small … Read more

Efficient generation of human dendritic cells from iPSC by introducing a feeder-free expansion step for hematopoietic progenitors​Zahra Elahi on 16 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 16:qiaf045. doi: 10.1093/jleuko/qiaf045. Online ahead of print. ABSTRACT Dendritic cells (DCs) are rare innate immune cells that are essential regulators of anti-tumour, anti-viral and vaccine responses by the adaptive immune system. Conventional dendritic cells, particularly the cDC1 subset, are most desired for DC-based immunotherapies, however, it can be difficult to … Read more

Targeting cancer-associated glycosylation for adoptive T cell therapy of solid tumors

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Cancer Immunol Res. 2025 Apr 16. doi: 10.1158/2326-6066.CIR-24-1050. Online ahead of print. ABSTRACT CAR T-cell therapy has improved outcomes for patients with chemotherapy-resistant B-cell malignancies. However, CAR T-cell treatment of patients with solid cancers has been more difficult, in part because of the heterogeneous expression of tumor-specific cell surface antigens. Here, we describe the generation … Read more

Impact of CD4+ T cell and TCR repertoires on SARS-CoV-2-Specific antibody responses in PLWH following COVID-19 vaccination

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J Immunol. 2025 Apr 15:vkae040. doi: 10.1093/jimmun/vkae040. Online ahead of print. ABSTRACT In people living with human immunodeficiency virus (HIV, PLWH), the coronavirus disease 2019 (COVID-19) vaccine often results in a limited humoral immune response. While a reduced absolute CD4+ T cell count is a known factor, other determinants remain unclear. To investigate variables influencing … Read more

Single-cell analysis of pig lung leukocytes and their response to influenza infection and oseltamivir therapy

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J Immunol. 2025 Apr 15:vkaf032. doi: 10.1093/jimmun/vkaf032. Online ahead of print. ABSTRACT Despite pigs being an important species in influenza A virus (IAV) epidemiology and a reliable preclinical model for human IAV infections, many aspects of the porcine pulmonary immune system remain poorly understood. Here, we characterized the single-cell landscape of lung leukocytes of healthy … Read more

ICOS+ CD4+ T cells promote antitumor immunity through Akt/STAT1/T-bet axis in MSS/pMMR colorectal cancer

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J Immunol. 2025 Apr 15:vkaf040. doi: 10.1093/jimmun/vkaf040. Online ahead of print. ABSTRACT Inducible Co-Stimulator (ICOS), as a T-cell-specific costimulatory receptor that enhances T-cell responses to foreign antigens, plays a crucial role in cancer immunity. However, its role in MSS/pMMR colorectal cancer (CRC) remains unclear. In this study, we demonstrated that ICOS expression decreases as the … Read more

Depletion of Natural Killer Cells Enhances Wound Healing in Diabetic Mice​Jacqueline Cavalcante-Silva on 16 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 16:qiaf044. doi: 10.1093/jleuko/qiaf044. Online ahead of print. ABSTRACT Natural Killer (NK cells) are known for their killing function in infection- and tumor-related responses, but also can shape immune responses involved in physiological processes such as wound healing. We recently reported that NK cells accumulate in skin wounds and express pro-inflammatory … Read more

Safety and Diagnostic Utility of Brain Biopsy and Metagenomics in Decision-Making for Patients with Inborn Errors of Immunity (IEI) and Unexplained Neurological Manifestations

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J Clin Immunol. 2025 Apr 16;45(1):86. doi: 10.1007/s10875-025-01878-y. ABSTRACT Unexplained neurological symptoms can pose a diagnostic challenge in patients with inborn errors of immunity (IEI) where the aetiology can be varied, and diverse pathologies may require contrasting treatments. Brain biopsy, the process of sampling brain tissue directly, has historically provided histological and microbiological information and … Read more

Investigating Polyreactivity of CD4+ T Cells to the Intestinal Microbiota. [[{“value”:”Ahmed Saadawi, Florian Mair, Esther Rosenwald, Daniel Hoces, Emma Slack, Manfred Kopf”}]]

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T-cell recognition of microbiota-derived epitopes is key to immune homeostasis. Here, we used an unbiased screening platform to identify novel immunogenic epitopes from Akkermansia muciniphila and Bacteroides thetaiotaomicron. We demonstrated that these epitopes are conserved across multiple other bacterial strains, suggesting their potential relevance in broader immune interactions. ABSTRACT Antigen-specific recognition of microbiota by T … Read more

Metabolic Dialogue Shapes Immune Response in the Tumor Microenvironment. [[{“value”:”Fengxia Gao, Rushil Shah, Gang Xin, Ruoning Wang”}]]

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Metabolic antagonism in the TME suppresses CD8+ T cell function by depleting essential nutrients and generating toxic byproducts. Metabolic symbiosis between tumor cells and TAMs fosters an immunosuppressive microenvironment. Disrupting metabolic interactions can overcome immune suppression, boost antitumor immunity, and enhance immunotherapy efficacy. ABSTRACT The fate of immune cells is fundamentally linked to their metabolic … Read more

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