inmunoadmin

Rapid Detection of Anti‐IFN‐α2 Autoantibodies Using a New Automated VIDAS Assay Prototype. [[{“value”:”Sylvie Pons, Laurence Generenaz, Adrian Gervais, Anne Puel, Paul Bastard, Nathalie Renard, Valerie Guyot, Cecile Vinit, Fei Zheng, Karen Brengel‐Pesce, Kahina Saker, Jean‐Christophe Richard, Alexis Mathian, Zahir Amoura, Karim Dorgham, Guy Gorochov, Jean‐Laurent Casanova, Aurore Fleurie, Sophie Trouillet‐Assant”}]]

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Autoantibodies neutralizing Type I interferons increase the risk of severe viral diseases and are linked to autoimmune conditions. The automated VIDAS assay is suitable for anti-IFN-α2 IgGs quantification, offering a swift, reliable, user-friendly, single test for clinical management.

Living on the edge: Mucus-associated microbes in the colon. Mihovil Joja

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Mucosal Immunol. 2025 Apr 13:S1933-0219(25)00041-8. doi: 10.1016/j.mucimm.2025.04.003. Online ahead of print. ABSTRACT The colonic mucus layer acts as a physicochemical barrier to pathogen invasion and as a habitat for mucus-associated microbes. This mucosal microbiome plays a crucial role in moderating mucus production, maintaining barrier integrity, and shaping the host immune response. However, unchecked mucin foraging … Read more

Hematopoietic stem and progenitor cells fine-tunning the “sweet” of trained immunity​Jiawei Li on 15 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 15:qiaf043. doi: 10.1093/jleuko/qiaf043. Online ahead of print. ABSTRACT Recent studies have challenged the traditional view of innate immunity as non-specific and transient by demonstrating that innate immune cells can develop immune memory in response to various activating factors, a phenomenon known as trained immunity. This process involves epigenetic modifications, such … Read more

T-cell Senescence in the Tumor Microenvironment

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Cancer Immunol Res. 2025 Apr 15:OF1-OF15. doi: 10.1158/2326-6066.CIR-24-0894. Online ahead of print. ABSTRACT T-cell senescence occurs in the tumor microenvironment (TME) and influences cancer outcomes, as well as the effectiveness of immunotherapies. The TME triggers this T-cell senescence via multiple pathways, including persistent stimulation with tumor-associated antigens, altered metabolic pathways, and activation of chronic inflammatory … Read more

A multi-omics microbiome signature is associated with the benefits of gastric bypass surgery and is differentiated from diet induced weight loss through 2 years of follow-up. Vancheswaran Gopalakrishnan

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Mucosal Immunol. 2025 Apr 11:S1933-0219(25)00040-6. doi: 10.1016/j.mucimm.2025.04.002. Online ahead of print. ABSTRACT Roux-en-Y gastric bypass (GBP) surgery is an effective treatment for reducing body weight and correcting metabolic dysfunction in individuals with severe obesity. Herein, we characterize the differences between very low energy diet (VLED) and GBP induced weight loss by multi-omic analyses of microbiome … Read more

Autoimmune-related adverse events induced by immune checkpoint inhibitors

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Curr Opin Immunol. 2025 Apr 11;94:102556. doi: 10.1016/j.coi.2025.102556. Online ahead of print. ABSTRACT Targeted immunotherapies, particularly immune checkpoint inhibitors (ICIs), have transformed cancer treatment by significantly improving patient response and survival rates. However, ICIs could disrupt self-tolerance, inducing the development of immune-related adverse events (irAEs). Most irAEs are classified as autoimmune conditions mediated by ICI-activated … Read more

What vaccines teach us about pathogen ecology. Alejandro Cabezas-Cruz

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Trends Immunol. 2025 Apr 10:S1471-4906(25)00080-8. doi: 10.1016/j.it.2025.03.006. Online ahead of print. ABSTRACT Vaccination campaigns have reshaped infectious disease dynamics, exerting selective pressures on pathogens. While some are controlled, others persist via antigenic variation or reservoirs. This Science & Society explores the evolutionary and ecological impacts of vaccination, highlighting its role in pathogen adaptation and implications … Read more

The unusual metabolism of germinal center B cells. Caitlin J Gracie

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Trends Immunol. 2025 Apr 11:S1471-4906(25)00058-4. doi: 10.1016/j.it.2025.02.015. Online ahead of print. ABSTRACT In the germinal center (GC), B cells undergo rounds of somatic hypermutation (SHM), proliferation, and positive selection to develop into high-affinity, long-lived plasma cells and memory B cells. It is well established that, upon activation, B cells significantly alter their metabolism, but until … Read more

Innate immunity of the lungs in homeostasis and disease. Peter A A Norris

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Mucosal Immunol. 2025 Apr 10:S1933-0219(25)00039-X. doi: 10.1016/j.mucimm.2025.04.001. Online ahead of print. ABSTRACT Humans breathe thousands of litres of non-sterile air each day containing bacteria, viruses, and fungi, as well as pollutants, allergens, and other particles. The continual exposure to foreign particles is juxtaposed with the vast surface area of the blood-air-barrier which becomes extremely thin … Read more

Cellular stress and macrophage activation. Jing Yu

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Semin Immunol. 2025 Apr 9;78:101953. doi: 10.1016/j.smim.2025.101953. Online ahead of print. ABSTRACT Cellular stress responses are pivotal in maintaining tissue homeostasis and intricately linked with various diseases. Macrophages, a key player of innate immune system, exhibit remarkable plasticity and responsiveness to environmental cues. In response to various cellular stresses, macrophages contribute to tissue homeostasis and … Read more

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