inmunoadmin
Peptide-driven identification of TCRs reveals dynamics and phenotypes of CD4 T cells in tuberculosis
J Immunol. 2025 Nov 16:vkaf287. doi: 10.1093/jimmun/vkaf287. Online ahead of print. ABSTRACT Assigning antigen specificity to T cell receptor (TCR) sequences is challenging due to the TCR repertoire’s diversity and the complexity of TCR-antigen recognition. We developed the peptide-driven identification of TCRs (PDI-TCR) assay that combines in vitro expansion of cells with peptide pools, bulk … Read more
Corrigendum “RIPK3 and Caspase-8 interpret cytokine signals to regulate ILC3 survival in the gut”. [Mucosal Immunol. 17/6 (2024) 1212-1221]. Ann M Joseph
Mucosal Immunol. 2025 Nov 14:S1933-0219(25)00119-9. doi: 10.1016/j.mucimm.2025.11.002. Online ahead of print. NO ABSTRACT PMID:41241599 | DOI:10.1016/j.mucimm.2025.11.002
Iron-Dependent allergenicity of Alt a 1: A link between fungal nutritional immunity and allergic sensitization. Aila Fakhimahmadi
Mucosal Immunol. 2025 Nov 13:S1933-0219(25)00123-0. doi: 10.1016/j.mucimm.2025.11.006. Online ahead of print. ABSTRACT The major fungal allergen Alt a 1 from Alternaria alternata is linked to allergic asthma. We assessed its biological role in nutritional immunity to iron and its allergenic potential using in silico, in vitro, and in vivo approaches. Alternaria was cultured with or … Read more
Grass carp (Ctenopharyngodon idella) SMYD3 negatively regulates antiviral innate immunity by methylating IRF3 and IRF7 during GCRV infection
J Immunol. 2025 Nov 15:vkaf311. doi: 10.1093/jimmun/vkaf311. Online ahead of print. ABSTRACT Interferon regulatory factors 3 and 7 (IRF3 and IRF7, respectively), which serve as key transcription factors in interferon (IFN) activation, are tightly regulated by a variety of mechanisms, including multiple posttranslational modifications, to fulfill their normal physiological functions. Nevertheless, the methylation-mediated regulation of … Read more
PPE18 protein of Mycobacterium tuberculosis functions as a virulence factor and is a potential novel therapeutic target
J Immunol. 2025 Nov 15:vkaf146. doi: 10.1093/jimmun/vkaf146. Online ahead of print. ABSTRACT Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that employs several strategies to evade the host immune system to establish a favorable niche inside the macrophages. One of the major immune evasion strategies involves induction of T helper 2 (Th2)-type response, which in turn … Read more
S100A4 Induces Neutrophilic Inflammation in Chronic Rhinosinusitis with Nasal Polyps via TLR4 Pathway
J Clin Immunol. 2025 Nov 15;45(1):160. doi: 10.1007/s10875-025-01953-4. ABSTRACT BACKGROUND: Treating neutrophilic inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) remains a challenge. Managing excessive infiltration and activation of neutrophils in tissues is important for improving CRSwNP outcomes. S100A4, a calcium-binding protein, regulates cell migration, chemotaxis and tissue fibrosis. In this study, we sought to … Read more
Bronchiectasis, Low IgG Levels and Lack of Vaccination are Risk Factors for Covid-19 Hospitalization in X-linked Agammaglobulinemia – A Retrospective Multicenter Study
J Clin Immunol. 2025 Nov 15;45(1):161. doi: 10.1007/s10875-025-01962-3. ABSTRACT X-linked agammaglobulinemia (XLA) is caused by loss-of-function variants in Bruton’s tyrosine kinase, leading to absence of circulating B lymphocytes and inability to produce antibodies. Despite the fear that patients with XLA would be at high risk for severe infection when the novel virus SARS-CoV-2 emerged in … Read more
Spatial Immunometabolism: Integrating Technologies to Decode Cellular Metabolism in Tissues. Felix J. Hartmann
This review highlights recent advances that enable spatially resolved analysis of immunometabolism within tissue microenvironments. Integrating mass spectrometry imaging, vibrational microscopy, and spatial omics reveals how metabolic organization shapes immune function in cancer and other pathologies. ABSTRACT The metabolic programs of immune cells influence their activation, differentiation, and effector functions. While much of immunometabolism has … Read more
Divergent Effects of Cytomegalovirus and Rheumatoid Arthritis on Senescent CD4+ T Cells. [[{“value”:”Lea Williams, Ali O. Saber, Silina Awad, Xi Su, Asgar Ansari, Ruozhang Xu, Hannah Jung, Anupama Shahane, Joshua F. Baker, Laura F. Su”}]]
How chronic immune stimulations differentially shape CD4⁺ T cell senescence remains unclear. Using high-dimensional mass cytometry and functional profiling, we show that cytomegalovirus (CMV) drives expansion of cytotoxic CD27−CD28− CD4⁺ T cells, whereas rheumatoid arthritis (RA) exerts nonredundant effects by modulating their effector capacity. ABSTRACT Chronic antigen exposure drives CD4⁺ T cell senescence, yet how … Read more