inmunoadmin

An MR1-specific nanobody capable of blocking MR1T cell activation

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J Immunol. 2026 Jun 7;215(6):vkag094. doi: 10.1093/jimmun/vkag094. ABSTRACT MR1 is a non-polymorphic, ubiquitously expressed, MHC class I-like antigen-presenting molecule that presents small-molecule metabolites to T cells. Studies have shown that MR1 plays a role in microbial infection, inflammation, and tumor immunity. The antigens it presents include metabolites of microbial and self-origin as well as small-molecule … Read more

TGF-β controls developmental fate and functional identity of thymic γδ T cells

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J Immunol. 2026 Jun 7;215(6):vkag134. doi: 10.1093/jimmun/vkag134. ABSTRACT Gamma delta (γδ) T cells undergo a distinct developmental pathway within the thymus, where transforming growth factor β (TGF-β) exerts pivotal regulatory influence. However, the precise mechanistic contributions of TGF-β to γδ T cells differentiation and functional maturation remain incompletely understood. Here, we show that TGF-β regulates … Read more

VISTA+ neutrophils contribute to platinum resistance by suppressing CD8+T cells in high-grade serous ovarian cancer

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Cancer Immunol Res. 2026 Jul 2. doi: 10.1158/2326-6066.CIR-25-1118. Online ahead of print. ABSTRACT Elevated neutrophil-to-lymphocyte ratio (NLR) has been associated with platinum resistance and poor outcomes in high-grade serous ovarian cancer (HGSOC), but the biological basis of this association remains unclear. We retrospectively analyzed 434 patients with HGSOC treated with platinum-based chemotherapy and found that … Read more

Cover Story: Eur. J. Immunol. 7’26.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?. [[{“value”:”Serena Bettoni, Ebba Qviberg, Edward Chaloner, Hayley Lavender, Maisem Laabei”}]]

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Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway-selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral, and fungal infections, with encapsulated bacteria at the highest risk (Neisseria meningitidis, … Read more

Generation of Regulatory T Cells Against Islet Neoantigen. [[{“value”:”Nicoline H. M. Den Hollander, Chelsea Gootjes, Maurits G. Staal, Antoinette M. Joosten, Tatjana Nikolic, Bart O. Roep, Diahann T. S. L. Jansen”}]]

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Naïve T cells against islet neoantigen exist in peripheral blood that can be primed ex vivo to become regulatory T cells despite the high immunogenic potential of neoantigen. These neoantigen-induced Tregs show complete suppressive capacity and phenotype indistinguishable from autoantigen-induced Tregs. Created in BioRender (2026). ABSTRACT Type 1 diabetes (T1D) results from T cell-mediated destruction … Read more

Fast Generation of F(Ab’)2 Fragments From Human IgG Using Fc‐Fused IgG‐Degrading Enzyme. [[{“value”:”Emna Hannachi, Robin V. Lacombe, Amélia Trecco, Victoria Daventure, Sandrine Delignat, Jordan D. Dimitrov, Claire Deligne, Sébastien Lacroix‐Desmazes”}]]

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Removal of Fc-fragments from human IgG or Fc-fused proteins. (1) IgG or Fc-fusion proteins are incubated with IdeS-Fc; (2) Fc fragments are retained using protein G agarose beads; and (3) the F(ab’)2 fragments or Fc-free proteins are collected by centrifugation in the original buffer without IdeS contamination.

4-1BBL on monocyte lineage cells rather than on classical dendritic cells drives CD8+ T cell accumulation in the respiratory tract and protects from severe respiratory influenza infection. Karen K M Yeung

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Mucosal Immunol. 2026 Jul 1:100374. doi: 10.1016/j.mucimm.2026.100374. Online ahead of print. ABSTRACT Seasonal epidemics and the persistent threat of a pandemic provide a strong impetus to understand mechanisms of protection against influenza infection. T cell intrinsic signaling through the TNFR superfamily member 4-1BB is critical for the accumulation of antigen-specific CD8+ effector and memory T … Read more

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