inmunoadmin
BAMBI: A novel regulator of intestinal epithelial integrity in the control of colitis and colon cancer progression. Marta Muñoz
Mucosal Immunol. 2026 Jun 30:100373. doi: 10.1016/j.mucimm.2026.100373. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease affects approximately 7 million individuals worldwide. Its pathogenesis involves genetic susceptibility, alterations in the gut microbiota, and immune system imbalance, with both innate and adaptive components contributing through aberrant cytokine signaling. The … Read more
Getting on your last nerve: IFNs and resistance to infection
J Immunol. 2026 Jun 7;215(6):vkag169. doi: 10.1093/jimmun/vkag169. ABSTRACT Interferons (IFNs) affect almost all nucleated cells and induce transcriptional events that are associated with control of intracellular infections as well as regulatory pathways that influence inflammatory processes. How different hematopoietic and non-hematopoietic cell types interpret these signals is a reflection of cellular context and function. For … Read more
Multinucleated giant cells in human pancreatic cancer are a distinct macrophage population undergoing a DNA damage response and associated with an aggressive tumor microenvironment
Cancer Immunol Res. 2026 Jun 30. doi: 10.1158/2326-6066.CIR-25-1602. Online ahead of print. ABSTRACT Macrophages constitute a dominant and functionally diverse immune population within the microenvironment of pancreatic ductal adenocarcinoma (PDAC), yet how macrophage heterogeneity contributes to the tumor remains poorly defined. In an institutional cohort of 145 PDAC specimens, we identified a population of multinucleated … Read more
Distinct lymphocyte immune signatures to nivolumab and recombinant IL-7 ex vivo in patients with sepsisTimothy Arthur Chandos Snow on 30 de June de 2026 at 10:00
J Leukoc Biol. 2026 Jun 8;118(6):qiag057. doi: 10.1093/jleuko/qiag057. ABSTRACT Therapeutic modulation of sepsis-induced immune dysfunction by targeting lymphocyte dysfunction with recombinant IL-7 (rIL-7) and anti-PD-1 (e.g. nivolumab) has shown promise in preclinical and early clinical studies. Prior to conducting large randomized controlled trials, an in-depth understanding of the changes induced by rIL-7 or nivolumab (and … Read more
yEFIS 3rd Symposium, 29th June–1st July, 2026, Prague, Czech Republic.
European Journal of Immunology, Volume 56, Issue S1, June 2026.
Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function
J Immunol. 2026 Jun 7;215(6):vkag165. doi: 10.1093/jimmun/vkag165. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment (TME) in which cancer-associated fibroblasts (CAFs) play pivotal roles in shaping therapeutic responses. Among these, MHC-II-expressing antigen-presenting CAFs (apCAFs) modulate CD4 T-cell activity, yet their contribution to the antitumor immune response remains unclear. Using tumor clones … Read more
A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs
Curr Opin Immunol. 2026 Jun 29;101:102809. doi: 10.1016/j.coi.2026.102809. Online ahead of print. ABSTRACT The fate of T cells is determined through the expression of a unique T cell receptor (TCR). TCR epitope specificity drives spatial localization, phenotypic and metabolic plasticity, effector function, as well as the evolution of complex repertoires of T cell clones. However, … Read more
MHC class II on melanoma cells regulates the anti-tumor T cell response
J Immunol. 2026 Jun 7;215(6):vkag158. doi: 10.1093/jimmun/vkag158. ABSTRACT In human melanoma, tumor cell-specific MHC class II expression is associated with improved response to programmed death 1 and programmed death-ligand 1 blockade; yet the direct effect of melanoma cell-specific MHC class II expression on anti-melanoma T cell responses remains largely unknown. In the clinically relevant Yale … Read more
ENPP1-dependent USP2 ubiquitination governs SQSTM1-mediated autophagy-dependent ferroptosis in trophoblast cells and exacerbates placental dysfunction in gestational diabetes mellitus
J Immunol. 2026 Jun 7;215(6):vkag127. doi: 10.1093/jimmun/vkag127. ABSTRACT Downregulation of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) has been implicated in autophagic cell death. However, how ENPP1 regulates the interplay between autophagy and ferroptosis to maintain trophoblast homeostasis in the context of gestational diabetes mellitus (GDM) remains unclear. To determine ENPP1’s role in autophagy-dependent ferroptosis and its contribution … Read more