inmunoadmin

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection

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Curr Opin Immunol. 2026 Jun 22;101:102805. doi: 10.1016/j.coi.2026.102805. Online ahead of print. ABSTRACT Solid‑phase assays for the detection of antiphospholipid antibodies (aPL) are central to the laboratory evaluation of antiphospholipid syndrome (APS). Growing insights into the molecular immunology underlying these assays challenge traditional interpretations. It is now evident that the antigenic drivers are phospholipids (PL)‑binding … Read more

Adaptive immune responses against Lachnospiraceae-derived flagellins and their role in inflammatory bowel disease. Daniëlle M H Barendregt

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Mucosal Immunol. 2026 Jun 22:100365. doi: 10.1016/j.mucimm.2026.100365. Online ahead of print. ABSTRACT Adaptive immune responses, including B and T cell responses, play important roles in establishing and maintaining the mutualistic relationship between the host and intestinal microbiota. Host-microbiota mutualism is disrupted in various immune-mediated inflammatory diseases, including Crohn’s disease (CD). Aberrant inflammatory memory CD4+ T … Read more

Cancer intrinsic protein neddylation modulates the intra-tumoral immune landscape to constrain immune checkpoint blockade therapy

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Cancer Immunol Res. 2026 Jun 22. doi: 10.1158/2326-6066.CIR-25-1309. Online ahead of print. ABSTRACT The cancer intrinsic network controlling response to immune checkpoint blockade therapy remains elusive. Using a published single-cell RNA sequencing (scRNA-seq) dataset from breast cancer patients, we found that pre-therapy mRNA expression of NEDD8, which encodes the regulatory protein essential for neddylation, in … Read more

An optimized method to differentiate HL60 cells into neutrophil-like cells​Samuel P Collie on 22 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 22:qiag081. doi: 10.1093/jleuko/qiag081. Online ahead of print. ABSTRACT The HL60 promyelocytic leukemia cell line is widely used to investigate neutrophil biology due to its genetic tractability and accessibility. HL60 cells can be differentiated into neutrophil-like cells using all-trans retinoic acid (ATRA) or dimethyl sulfoxide (DMSO) treatment. However, these approaches produce … Read more

Bacterial transfer-messenger RNA activates antiviral RNA sensing to induce inflammatory innate immune responses

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J Immunol. 2026 Jun 7;215(6):vkag149. doi: 10.1093/jimmun/vkag149. ABSTRACT Pathogen-derived RNAs function as pathogen-associated molecular patterns (PAMPs) that activate innate immune responses through pattern recognition receptors (PRRs). While viral RNA is well established as a trigger of antiviral immunity, the identity of bacterial RNA species that function as immunostimulatory ligands and the host PRRs that recognize … Read more

From the gut to the lung: microbiota-associated metabolites as regulators of respiratory immunometabolism. Jun-Yan Xiang

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Mucosal Immunol. 2026 Jun 21:100364. doi: 10.1016/j.mucimm.2026.100364. Online ahead of print. ABSTRACT The development and progression of respiratory diseases are influenced by both the local pulmonary microenvironment and the intestinal ecosystem. Research on the gut-lung axis has shown that diverse small-molecule metabolites produced or modified by the gut microbiota can cross the intestinal barrier and … Read more

Disease progression is associated with differential neutrophil maturation in Mycobacterium tuberculosis-infected macaques

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J Immunol. 2026 Jun 7;215(6):vkag114. doi: 10.1093/jimmun/vkag114. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is associated with clinical diversity and outcomes ranging from latent TB to active TB with distinct pathophysiologies. However, our understanding of the innate immune mechanisms related to the protection or progression of TB is limited. Among innate immune cells, the … Read more

BPTF is essential for vaccine-induced germinal center B cell responses

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J Immunol. 2026 Jun 7;215(6):vkag126. doi: 10.1093/jimmun/vkag126. ABSTRACT Germinal centers (GCs) are microanatomical structures in which antigen-specific B cells undergo proliferation, somatic hypermutation, and affinity-based competition to select high-affinity clones that differentiate into memory B cells and plasma cells (PCs). B cell progression through the GC is tightly regulated, and the molecular determinants that modulate … Read more

Mechanisms and functions of intercellular mitochondria transfer to and from macrophages

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J Immunol. 2026 Jun 7;215(6):vkag147. doi: 10.1093/jimmun/vkag147. ABSTRACT Cell-to-cell communication is essential for maintaining homeostasis and coordinating complex biological processes in multicellular organisms. Classically, cells communicate using secreted peptides and metabolites and through cell contact-dependent signaling. Emerging studies over the past 20 years indicate that many cell types, including innate immune cells such as macrophages, … Read more

Complement in Traumatic Brain Injury: Linking Acute Injury to Chronic Neurodegeneration. [[{“value”:”Ariana Chacon, Roy Raheb Khelo, Layth J.M. Saada, Jonathan A. Grossberg, Andrew Reisner, Ali M. Alawieh, Stephen Tomlinson”}]]

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Complement activation links acute traumatic brain injury to chronic neuroinflammation, maladaptive synaptic pruning, and progressive cognitive decline. These findings support targeted complement inhibition, particularly at the level of C3, as a promising strategy to preserve synaptic integrity and reduce long-term neurodegenerative sequelae after TBI. ABSTRACT Traumatic brain injury (TBI) is increasingly recognized not only as … Read more

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