Hypoproteinemia and Hypogammaglobulinemia Due to a Homozygous FCGRT Mutation
J Clin Immunol. 2026 Jun 8;46(1):63. doi: 10.1007/s10875-026-02032-y. NO ABSTRACT PMID:42260249 | DOI:10.1007/s10875-026-02032-y
inmunoadmin
Systematic Review and Meta-analysis of Anti-interferon Auto-antibodies in Infectious Diseases
J Clin Immunol. 2026 Jun 9. doi: 10.1007/s10875-026-02038-6. Online ahead of print. ABSTRACT PURPOSE: To perform a systematic review and meta-analysis of prevalence and function of anti-interferon auto-antibodies in acute infectious diseases. METHODS: We performed a search on the following electronic bibliographic databases: Medline, Embase, Web of Science and Cochrane. Eligible studies generated a systematic … Read more
Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of Cd3g expression
J Immunol. 2026 Jun 7;215(6):vkag124. doi: 10.1093/jimmun/vkag124. ABSTRACT Group 2 innate lymphoid cells (ILC2s) are thought to develop in the bone marrow and fetal liver. However, increasing evidence supports the presence of thymic ILC2s in mice and humans. In this study, we introduce a novel fate-mapping mouse model designed to track thymic ILC2s in peripheral … Read more
Adjuvants orchestrate cross-organ induction of mucosal CD8+ T cell immune responses in respiratory tracts
J Immunol. 2026 Jun 7;215(6):vkag117. doi: 10.1093/jimmun/vkag117. ABSTRACT Mucosal immunity is paramount for combating respiratory infections, but conventional vaccination methods, such as intramuscular injection, often struggle to induce it. Although direct mucosal vaccination is effective, it carries an increased risk of respiratory adverse effects, making it particularly challenging for individuals with chronic respiratory diseases. Consequently, … Read more
IFITM1 differentially regulates antibacterial immunity and immunopathology but is dispensable for antiparasitic responses
J Immunol. 2026 Jun 7;215(6):vkag122. doi: 10.1093/jimmun/vkag122. ABSTRACT Interferon-induced transmembrane (IFITM) proteins underpin antiviral responses, yet their role in bacterial infections remains underexplored, particularly for parasites. We probed the role of IFITM1 in Mycobacterium tuberculosis (Mtb), Listeria monocytogenes (Lm), and Leishmania major infection using IFITM1 knockout mice. Notably, IFITM1 was upregulated in murine and human … Read more
Chronic stress at the crossroads: Decoding the HPA-SAM-immune-gut axis in inflammatory bowel disease pathogenesis and therapeutics. Ya-Fang Zhang
Semin Immunol. 2026 Jun 6;83:102038. doi: 10.1016/j.smim.2026.102038. Online ahead of print. ABSTRACT Stress, a prevalent factor in modern life, profoundly impacts human health by disrupting immune function and intestinal homeostasis. This review elucidates the mechanisms through which stress dysregulates the hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal medulla (SAM) axes, leading to altered glucocorticoid and catecholamine levels that … Read more
Sombrero vesicles: from overlooked structures to primary mediators of eosinophil secretionRossana C N Melo on 6 de June de 2026 at 10:00
J Leukoc Biol. 2026 Jun 5:qiag072. doi: 10.1093/jleuko/qiag072. Online ahead of print. ABSTRACT Eosinophils, cells of the innate immune system, have a unique architecture, which includes morphologically complex secretory granules and a prominent, activation-responsive vesiculotubular system. In human eosinophils, this system is collectively termed eosinophil sombrero vesicles (EoSVs) because of its peculiar morphology feasibly identifiable … Read more
SIRT6 bridges glycolysis and epigenetics to neutrophilic asthma. Zhan Wang
Trends Immunol. 2026 Jun 5:S1471-4906(26)00127-4. doi: 10.1016/j.it.2026.05.002. Online ahead of print. ABSTRACT Neutrophil asthma is a severe, corticosteroid-resistant subtype characterized by airway neutrophilia and declining lung function. Su et al. identify a sirtuin 6-lactate dehydrogenase A-histone lactylation axis that links macrophage glycolysis to epigenetic chemokine regulation, offering mechanistic insight into neutrophil recruitment and highlighting potential … Read more
Protein tyrosine kinases in dendritic cell-mediated anti-cancer immunity. Misha Mao
Semin Immunol. 2026 Jun 5;83:102037. doi: 10.1016/j.smim.2026.102037. Online ahead of print. ABSTRACT Dendritic cells (DCs), the most proficient antigen-presenting cells, bridge innate and adaptive immunity and are critical for anti-cancer immune surveillance. Their function is precisely regulated by protein tyrosine kinases (PTKs), which integrate signals from external stimuli and internal cellular stress to control DC … Read more
SIV infection induces aging-like alterations in cardiac cellularity and macrophage populations of rhesus macaquesDaniel I Petkov on 5 de June de 2026 at 10:00
J Leukoc Biol. 2026 Jun 5:qiag069. doi: 10.1093/jleuko/qiag069. Online ahead of print. ABSTRACT People living with HIV experience an earlier risk for onset of aging-related chronic inflammatory comorbidities including cardiovascular disease. We previously showed that the proportion of macrophages was higher in the heart of older rhesus macaques (Macaca mulatta) with normal histopathology as well … Read more