inmunoadmin

Pro‐ and Anti‐Inflammatory Macrophages Adjust UCP2 Protein Levels Based on Their Intrinsic Metabolism and Available Metabolites. [[{“value”:”Jila Nasirzade, Felix Sternberg, Andrea Vogel, Roko Sango, Taraneh Beikbaghban, Thomas Kolbe, Thomas Rattei, Thomas Weichhart, Elena E. Pohl”}]]

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LPS-stimulated macrophages exhibit high glycolytic flux, with pyruvate preferentially converted to lactate even under normoglycemic conditions, limiting pyruvate availability for the tricarboxylic acid (TCA) cycle and reducing oxygen consumption rate (OCR). Glucose deprivation increases OCR; however, an innate hypoxic state is associated with low UCP2 levels in this phenotype. In contrast, under normal glucose conditions, … Read more

Identifying Negative Biomarkers of CD4 Cytotoxic T Lymphocytes via Granzyme B Exclusion Analysis. [[{“value”:”Bingsu Wang, Ayibaota Bahabayi, Danyi Huang, Ziqi Xiong, Zhonghui Zhang, Yiming Gao, Wenling Han, Chen Liu, Pingzhang Wang”}]]

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Given the relatively high level of coexistence, a nonlinear model is more suitable for mutual exclusion than a linear model. Based on mutual exclusion, negative markers were identified for CD4+ cytotoxic T cells, particularly CD126. However, according to FACS analysis, CD28 is the most effective cell surface negative marker. ABSTRACT CD4 cytotoxic T lymphocytes (CTLs) … Read more

Multi-cohort transcriptomic analysis with machine learning identifies interferon-related candidate genes in systemic lupus erythematosus. [[{“value”:”Aishanjiang Apaer Alimijiang Aobulitalifu Jumahong Keyoumu Adilijiang Alifu Alimu Aikebaier Milikanmu Hasimu Yanyan Shi Maierhaba Sulitan a Department of Pharmacy, The First People’s Hospital of Kashi Prefecture, Xinjiang, China b Department of Pediatrics, The First People’s Hospital of Kashi Prefecture, Xinjiang, China”}]]

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Volume 59, Issue 1, December 2026.

TGF-β: A master regulator of tissue-resident macrophage identity and function. Clarissa-Laura Döring

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Trends Immunol. 2026 Jun 9:S1471-4906(26)00128-6. doi: 10.1016/j.it.2026.05.003. Online ahead of print. ABSTRACT Tissue-resident macrophages exhibit remarkable plasticity, dynamically adapting to their local environment and adopting tissue-specific phenotypes that support organ homeostasis. The underlying identity-determining transcriptional programs are instructed by microenvironmental cues. Transforming growth factor-β (TGF-β), which has long been recognized for its role in immunosuppression, … Read more

CD7 drives CD8 T cell exhaustion during chronic viral infection

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J Immunol. 2026 Jun 7;215(6):vkag091. doi: 10.1093/jimmun/vkag091. ABSTRACT Viral or tumor persistence is often associated with CD8 T cell “exhaustion,” a differentiation process characterized by co-inhibitory receptor upregulation and loss of effector function. Recent data show that “exhausted” T cells are a heterogenous population that includes a progenitor subset that transitions through an intermediate state … Read more

Sustained antigen-specific CD8+ T cell immunity post-mRNA booster requires notch pathway activation

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J Immunol. 2026 Jun 7;215(6):vkag074. doi: 10.1093/jimmun/vkag074. ABSTRACT Messenger RNA (mRNA) vaccines effectively induce protective immunity, but antigen-specific CD8+ T cell responses exhibit limited persistence. In this study, we aimed to assess CD8+ T cell responses following a third dose of the Pfizer BNT162b2 COVID-19 vaccine and identify factors contributing to their longevity. Using HLA … Read more

Cancer chemo-immunotherapy: time will tell

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Cancer Immunol Res. 2026 Jun 8. doi: 10.1158/2326-6066.CIR-26-0335. Online ahead of print. ABSTRACT Endogenous circadian programs coordinate physiology across tissues, including immune cell trafficking and drug metabolism. Previous retrospective studies suggested that the timing of immune checkpoint inhibitor delivery may be a modifiable determinant of survival in patients with cancer, with earlier infusions often associated … Read more

ILT2 identifies an unexploited pool of intratumoral CD8+ bystander T cells with TCR-independent cytotoxicity in renal cell carcinoma

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Cancer Immunol Res. 2026 Jun 8. doi: 10.1158/2326-6066.CIR-25-1109. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICIs) have improved clear-cell renal cell carcinoma (ccRCC) therapy, yet many patients remain unresponsive. Alternative strategies are needed, and the HLA-G/ILT2 axis has emerged as a promising immunosuppressive pathway. Here, we deeply characterized CD8⁺ILT2⁺ tumor-infiltrating lymphocytes (TILs) as a … Read more

Sleep interruption aggravates sepsis by rewiring the macrophage immune response

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J Immunol. 2026 Jun 7;215(6):vkag130. doi: 10.1093/jimmun/vkag130. ABSTRACT Sepsis is the leading cause of death in hospitals and is very common in intensive care units (ICUs). Sleep is frequently interrupted in the hospital setting, especially within the ICU. Patients who sleep poorly have worse outcomes, such as increased mortality and longer hospital stays; however, the … Read more

Novel Partial Loss-of-function STAT3-variant as Cause of Hyper-IgE-Syndrome in a Danish Family with Variable Expressivity

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J Clin Immunol. 2026 Jun 8. doi: 10.1007/s10875-026-02036-8. Online ahead of print. ABSTRACT A novel heterozygous missense variant in STAT3 (NM_139276.3: c.1250G > C, NP_644805.1: p.(Arg417Thr) was identified in a Danish family spanning five generations with diverse phenotypes consistent with autosomal dominant STAT3-Hyper-IgE-Syndrome (STAT3-HIES). Genetic analysis confirmed the absence of the variant in population databases, … Read more

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