inmunoadmin

J Immunol. 2026 Feb 9;215(2):vkaf331. doi: 10.1093/jimmun/vkaf331. ABSTRACT Exposure to a diversity of microbes has been implicated in playing a major role in susceptibility to the development of allergic lung-type diseases. The hygiene hypothesis suggests that those exposed to a broad diversity of microbes are more likely to be protected against developing allergic-type diseases. However, … Read more

J Immunol. 2026 Feb 9;215(2):vkaf341. doi: 10.1093/jimmun/vkaf341. ABSTRACT Preterm birth is the leading cause of neonatal morbidity and mortality. Management of preterm labor relies on the use of tocolytics, like nifedipine, which fail to prevent preterm birth and related morbidities. Interleukin-1β plays significant roles in the pathophysiology of preterm birth including inflammation and uterine activation. … Read more

J Immunol. 2026 Feb 9;215(2):vkaf362. doi: 10.1093/jimmun/vkaf362. ABSTRACT Environmental temperature significantly influences immune responses. Cold exposure suppresses host defense against infections and exacerbates autoimmune and allergic conditions. However, the molecular mechanisms underlying temperature-dependent immune regulation remain unclear. In this study, we evaluated the cold-activated sympathetic modulation of immune responses. We presented that semaphorin 6D (Sema6D), … Read more

J Immunol. 2026 Feb 9;215(2):vkaf351. doi: 10.1093/jimmun/vkaf351. ABSTRACT Sepsis-induced liver injury involves profound immune dysregulation. Natural compounds such as artesunate (ART), capsaicin (CAP), and oridonin (ORI) have demonstrated efficacy in mitigating systemic inflammation; however, their comparative cellular mechanisms in sepsis remain poorly characterized. Here, we integrated and reanalyzed the single-cell transcriptomic datasets of murine livers … Read more