Colonic macrophage heterogeneity revealed by CD11c and CD163. Peiliang Cai
Mucosal Immunol. 2025 Dec 30:S1933-0219(25)00142-4. doi: 10.1016/j.mucimm.2025.12.006. Online ahead of print. NO ABSTRACT PMID:41478462 | DOI:10.1016/j.mucimm.2025.12.006
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Lactation, tissue-resident immunity, and protection against breast cancer. Martin Little
Trends Immunol. 2025 Dec 31:S1471-4906(25)00312-6. doi: 10.1016/j.it.2025.12.004. Online ahead of print. ABSTRACT Parity and lactation have long been recognised as protective factors in breast cancer, with notable risk reduction in triple negative breast cancer (TNBC). Recent work by Virassamy et al. suggests a tissue-specific, persistent immune surveillance underpins this effect, particularly in women who have … Read more
Gut dysbiosis in early severe burns contributes to acute lung injury by impairing neutrophil chemotaxisYuliang Sun on 30 de December de 2025 at 11:00
J Leukoc Biol. 2025 Dec 26;118(1):qiaf169. doi: 10.1093/jleuko/qiaf169. ABSTRACT Severe burns complicated by acute lung injury are critical causes of respiratory failure and multiple organ dysfunction syndrome. Neutrophils extensively infiltrate lung tissues early postburn to mediate pulmonary damage, but the underlying mechanisms remain unclear. We analyzed gut microbiota of severe burn patients via metagenomics and … Read more
Statin repurposing in gastrointestinal cancer: from metabolic reprogramming to immunoregulationMiaorong Xu on 30 de December de 2025 at 11:00
J Leukoc Biol. 2025 Dec 30:qiaf187. doi: 10.1093/jleuko/qiaf187. Online ahead of print. ABSTRACT Cholesterol metabolism plays a pivotal role in gastrointestinal (GI) cancers, from fuelling tumor growth, facilitating metastatic niche formation, shaping tumor immunosuppressive microenvironment to promoting immunotherapy resistance. Paradoxically, cholesterol may also exert context-dependent protective effects. Statins, the most widely prescribed cholesterol-lowering drugs, function … Read more
Regulatory T cells protect against aberrant remodeling in a mouse model of pulmonary fibrosis. Aditi Murthy
Mucosal Immunol. 2025 Dec 27:S1933-0219(25)00140-0. doi: 10.1016/j.mucimm.2025.12.004. Online ahead of print. ABSTRACT Regulatory T (Treg) cells are well recognized for their role in immune regulation; however, their role in tissue regeneration is not fully understood. This study demonstrates such a role of Tregs in a published preclinical murine model of spontaneous pulmonary fibrosis (PF) expressing … Read more
The CCL17-CCR4 axis is critical for mutant STAT6-mediated microenvironmental remodelling and therapeutic resistance in Relapsed/Refractory Diffuse Large B-cell Lymphoma
Cancer Immunol Res. 2025 Dec 29. doi: 10.1158/2326-6066.CIR-25-0583. Online ahead of print. ABSTRACT Relapsed and refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) presents a significant challenge in hematology-oncology, with approximately 30-40% of DLBCL patients experiencing relapse or resistance to treatment. This underscores the urgent need to better understand the molecular mechanisms governing therapeutic resistance. Signal Transducer … Read more
Thrombospondin‐1 Is a Contact Sensor Triggering Adhesion in T Cells and Platelets While Differentially Regulating 2D and 3D Motility in T Cells. Karl‐Gösta Sundqvist
The C-terminal of TSP-1 senses cell contact, which triggers N-terminal cleavage by urokinase, adhesion, and cytoplasmic spreading in T cells and platelets. In contrast, full-length TSP-1 induces the development of polar cell shape and migration in T cells 2D and 3D; polar cell shape 2D, independent of its receptor LRP1, and polar cell shape 3D … Read more
Dual regulation of coronin-1 expression by the core promoter and intronic regions
J Immunol. 2025 Dec 28:vkaf349. doi: 10.1093/jimmun/vkaf349. Online ahead of print. ABSTRACT Coronin family proteins are involved in various cellular processes, such as actin cytoskeleton reorganization, cell motility, and vesicular trafficking. Coronin-1, encoded by Coro1a, is specifically expressed in immune cells, and its defect causes severe immunodeficiencies. However, the regulatory mechanisms of Coro1a expression in … Read more
Altered B cell metabolic pathways characterize type 1 diabetes progression
J Immunol. 2025 Dec 27:vkaf330. doi: 10.1093/jimmun/vkaf330. Online ahead of print. ABSTRACT Type 1 diabetes (T1D) results from immune-mediated destruction of pancreatic beta cells. B cells serve as critical antigen-presenting cells whose autoreactive specificities drive disease progression. Conversely, IL-10 producing regulatory B cells (Bregs) exert immunosuppressive functions and have been shown to protect against autoimmunity … Read more