inmunoadmin

Significance of miRNA Profile of Regulatory T Cells (Tregs) After Baricitinib Treatment in Rheumatoid Arthritis Patients. [[{“value”:”Magdalena Massalska, Anna Felis‐Giemza, Patrycja Gardias, Tomasz Burakowski, Anna Kornatka, Paulina Klimek, Magdalena Plebanczyk, Marta Marecka‐Kuzdub, Weronika Kurowska, Ewa Kuca‐Warnawin, Wlodzimierz Maslinski, Marzena Ciechomska”}]]

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We analyzed the expression levels of miRNAs in Treg cells and thrombotic parameters in plasma of patients with rheumatoid arthritis (RA) before and after baricitinib (BARI) treatment. Four miRNAs were identified that showed a positive correlation with thrombotic parameters and were associated with an improved therapeutic response to BARI. ABSTRACT Several studies proved that microRNA … Read more

Modulation of host lung immunity in Pneumocystis pneumonia: a review of current concepts and future prospects for novel adjunctive immune-based therapies

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J Immunol. 2025 Oct 6:vkaf269. doi: 10.1093/jimmun/vkaf269. Online ahead of print. ABSTRACT Pneumocystis jirovecii pneumonia remains a significant cause of mortality and morbidity in immunocompromised populations worldwide. Mortality rates range from 5% to 30% in HIV-positive individuals and 4% to 76% in those without HIV. Recognizing its public health impact, the World Health Organization (WHO) … Read more

When granulomatous inflammation becomes visible: insights into cutaneous sarcoidosis

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Curr Opin Immunol. 2025 Oct 4;97:102673. doi: 10.1016/j.coi.2025.102673. Online ahead of print. ABSTRACT Cutaneous involvement of sarcoidosis can provide important insights into the presence and prognosis of systemic involvement. Recent insights into the underlying pathophysiology of sarcoidosis have allowed for more targeted therapy, including inhibition of the JAK-STAT and mTOR pathways. In this review article, … Read more

Germinal centre B cell disruption by non-typhoidal Salmonella. Francisco Osorio-Barrios

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Trends Immunol. 2025 Oct 3:S1471-4906(25)00226-1. doi: 10.1016/j.it.2025.09.007. Online ahead of print. ABSTRACT Salmonella enterica serovar Typhimurium (STm) represents a major global health burden. Strains endemic in sub-Saharan Africa cause life-threatening invasive non-typhoidal salmonellosis (iNTS) in vulnerable populations. Studies in the iNTS-like mouse model show that STm induces profound germinal centre (GC) disruption, impairing high-affinity, long-lived … Read more

Low‐Input Assay for Transposase‐Accessible Chromatin Identifies Epigenetic Signatures of Liver Group 1 Innate Lymphoid Cells. [[{“value”:”Kevin Schmid, Robin P. Schenk, Gabriela M. Wiedemann”}]]

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Assessing chromatin accessibility in rare cell populations within tissue remains a key challenge. To address this, we present a low-input ATAC workflow optimized for liver ILCs. The protocol is validated across cell numbers, Tn5 ratios, and library preparation steps and unveils unique epigenetic features of liver NK cells and ILC1s.

Potential impact of long-read sequencing on complement-mediated diseases. Sarah M Carpanini

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Trends Immunol. 2025 Oct 2:S1471-4906(25)00225-X. doi: 10.1016/j.it.2025.09.006. Online ahead of print. ABSTRACT The complement genes harbour genetic variants that affect numerous diseases; however, these genes are notoriously repeat-heavy, and these repeat regions are largely unexplored for disease-relevant genetic variation. Elucidating these ‘dark’ regions is now possible using long-read sequencing (LRS), enabling identification of novel disease-relevant … Read more

Impact of absent in melanoma 2 on head and neck squamous cell carcinoma development

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J Immunol. 2025 Oct 3:vkaf224. doi: 10.1093/jimmun/vkaf224. Online ahead of print. ABSTRACT Head and neck squamous cell carcinoma (HNSCC) constitutes 90% of head and neck cancers. HNSCC development is linked to chronic inflammation, while established HNSCC tumors are often immune suppressive. However, both occur through mechanisms that are not fully understood. The cytosolic double-stranded DNA … Read more

Diabetes and insulin resistance alters ligamentum flavum-derived fibroblast responses in an AKT2-dependent manner

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J Immunol. 2025 Oct 3:vkaf233. doi: 10.1093/jimmun/vkaf233. Online ahead of print. ABSTRACT Fibroblasts participate in inflammatory responses and play a critical role in the switch from acute to persistent inflammation. Whether fibroblast responses are modulated by signals from their microenvironment is not well established. Insulin signaling and insulin resistance modulate responsiveness of innate immune cells … Read more

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