Cellular & Molecular Immunology, Published online: 30 January 2026; doi:10.1038/s41423-026-01386-yTWEAK receptor (Fn14) exacerbates TNF-α-induced inflammation in rheumatoid arthritis synovial fibroblasts and influences response to …
J Leukoc Biol. 2026 Jan 29:qiag012. doi: 10.1093/jleuko/qiag012. Online ahead of print. ABSTRACT Novel leukolectin-proteins (LL-proteins) are present in multiple lower vertebrates. LL-proteins (∼255 AAs) possess five TECPR-domains spanning 4/5 of conserved AA-sequences, and are detected in dermal lectocytes, (primitive and tissue resident) macrophages and some leukocytes. Hatched fish embryos employ secreted LL-proteins for innate … Read more
The inducible T-cell co-stimulator (ICOS, CD278) represents an appealing yet complex target within the CD28 immunoglobulin receptor superfamily. Unlike constitutively expressed co-stimulatory molecules, ICOS is minimally present on naïve T cel…
Background
Myeloid-derived suppressor cells (MDSCs) have a dominating presence in the postoperative period, mediating the suppression of natural killer (NK) cells and promoting cancer metastases after surgery. However, their phenotype and effects on p…
J Leukoc Biol. 2026 Jan 28:qiag014. doi: 10.1093/jleuko/qiag014. Online ahead of print. ABSTRACT Mucosal associated invariant T (MAIT) cells are part of a T cell subset that is activated upon presentation of B2 vitamin (riboflavin) metabolites by the major histocompatibility complex, class I related (MR1) protein. Though there is a clear relationship between microbial production … Read more
J Leukoc Biol. 2026 Jan 28:qiag015. doi: 10.1093/jleuko/qiag015. Online ahead of print. ABSTRACT γδ T cells are enriched at barrier sites such as skin, gut and lung, where they protect against cancer and infections, and promote healing. They detect diverse ligands in T cell receptor-dependent or independent manners, producing large quantities of pro-inflammatory cytokines. γδ … Read more
Curr Opin Immunol. 2026 Jan 27;99:102726. doi: 10.1016/j.coi.2026.102726. Online ahead of print. ABSTRACT Malaria during pregnancy continues to compromise maternal, fetal, and subsequently infant health. This burden has increased in Africa, though it has decreased elsewhere. Here, we provide a concise review of recent findings on malaria in pregnancy, addressing pathogenesis, immunity, offspring outcomes, and … Read more
Purpose
This study was conducted to assess the clinical significance of programmed cell death-ligand 1 (PD-L1)-positive circulating tumor cells (CTCs) as predictive biomarkers for the efficacy of PD-(L)1 inhibitor-based treatment in advanced hepatocel…
Background
Nanosecond pulsed electric field (nsPEF) ablation has demonstrated limited and transient efficacy in suppressing tumor progression. Oncolytic peptide LTX-315 is known to elicit a strong antitumor immune response and durable immune memory. T…
