Nature Reviews Immunology, Published online: 31 October 2025; doi:10.1038/s41577-025-01231-9In this Review, Li and Underhill discuss recent advances in understanding the process of phagocytosis. The authors highlight how phagocytosis i…
J Immunol. 2025 Oct 1;214(10):2515-2522. doi: 10.1093/jimmun/vkaf244. ABSTRACT Rodent models for evaluating new cancer immunotherapies often fail to fully recapitulate the complexity of immune interactions that occur in cancer patients. Companion dogs with spontaneously developing cancers more closely resemble humans immunologically than rodents. This resemblance results in part because their immune systems have been educated … Read more
J Immunol. 2025 Oct 1;214(10):2504-2514. doi: 10.1093/jimmun/vkaf231. ABSTRACT Infection of eastern North American woodchucks (Marmota monax) with woodchuck hepatitis virus (WHV) represents the most valuable immunopathogenic model of hepatitis type B that, like in humans, can advance stepwise from acute hepatitis to chronic hepatitis and hepatocellular carcinoma (HCC) or become self-resolving and persist as a … Read more
J Immunol. 2025 Oct 1;214(10):2489-2491. doi: 10.1093/jimmun/vkaf163. NO ABSTRACT PMID:41169233 | DOI:10.1093/jimmun/vkaf163
J Immunol. 2025 Oct 1;214(10):2535-2542. doi: 10.1093/jimmun/vkaf236. ABSTRACT While rodent models remain foundational in biomedical research for their manipulability, genetics, and reproducibility, spontaneous diseases in companion animals provide relevant models to study naturally occurring conditions. Pathogenic processes underlying diseases in humans and dogs are similar or identical, which exemplifies the One Health concept. Companion animals … Read more
J Immunol. 2025 Oct 1;214(10):2492-2493. doi: 10.1093/jimmun/vkaf238. NO ABSTRACT PMID:41169231 | DOI:10.1093/jimmun/vkaf238
J Immunol. 2025 Oct 1;214(10):2523-2534. doi: 10.1093/jimmun/vkaf235. ABSTRACT Maternal immunity is critical for neonatal defense during early life, when infants are highly susceptible to infection. Antibodies transferred across the placenta or through breast milk not only provide immediate protection but also shape immune development. Defining the mechanisms and outcomes of this passive protection is essential … Read more
J Immunol. 2025 Oct 1;214(10):2494-2503. doi: 10.1093/jimmun/vkaf119. ABSTRACT While studies with laboratory rodent models have defined molecular and cellular components of the human immune system, experiments in these small mammals can’t capture all aspects of human immunity. This review focuses on immunologic research in large and agricultural species, highlighting how understanding immunity in a range … Read more
Emerging evidence highlights the critical role of time-of-day (ToD) in immunotherapy, with large-scale retrospective studies showing that administering immune checkpoint inhibitors (ICIs) earlier in the day is associated with significantly improved ef…
Purpose
This study evaluated the dynamic changes in the tumor microenvironment (TME) in patients with non-small cell lung cancer (NSCLC) and acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) using an arti…
