Frontiers in Immunology
Ferritin heavy chain 1 expression is correlated with plasma cell exhaustion and acts as a prognostic correlative marker in hepatocellular carcinoma
BackgroundImmunotherapy has emerged as a breakthrough in cancer treatment; however, the functional status of B lineage cells within the tumor microenvironment (TME) remains poorly characterized.ObjectiveThis study systematically profiles the heterogene…
Engineering immunity in osteosarcoma: nanomedicine strategies for overcoming immune evasion
Osteosarcoma is an aggressive malignancy characterized by inherent chemoresistance, a high propensity for pulmonary metastasis, and dismal survival rates in patients with advanced or refractory disease. While immunotherapy has revolutionized cancer tre…
Modular engineered outer membrane vesicles for synergistic cancer immunotherapy via PD-L1 blockade and epigenetic reprogramming
Immune checkpoint inhibitors have significantly improved therapeutic outcomes in advanced melanoma; however, their clinical efficacy is greatly limited by low overall response rates and the primary or acquired resistance. Here, we developed a SpyCatche…
Linoleoyl-lysophosphatidylcholine drives non-inflammatory apoptosis in neutrophils via lipid rafts
Lysophosphatidylcholines (LPCs) are among the most abundant circulating bioactive lipids, whose fatty acid compositions critically influence their immunomodulatory functions. Alterations in circulating LPC species have been implicated in inflammatory s…
Efficacy and safety of various immunosuppressive agents for pediatric Henoch-Schönlein purpura nephritis (IgA vasculitis nephritis) in Chinese children: a systematic review and network meta-analysis
BackgroundHenoch-Schönlein purpura nephritis (HSPN) is a common secondary glomerular disease in children. Approximately 30% of children with Henoch-Schönlein purpura develop this renal complication, and among them, about 20% may progress to chronic kid…
Biomarkers for myelin oligodendrocyte glycoprotein-associated disease: recent advances and future
MOGAD is a rare autoimmune encephalomyelitis that shares similar clinical manifestations with other central nervous system demyelinating diseases. However, they must be distinguished due to their distinct pathogenesis and treatment methods. Currently, …
Impact of immune function and white matter integrity on cognitive function in patients with bipolar disorder
IntroductionCognitive impairment significantly impacts social function in Bipolar disorder (BD). This study explores the link between immune markers, white matter microstructure, and cognitive function in depressed BD patients enhance early diagnosis a…
Revised porcine IgG subclass classification based on innate immune cell activation
The current classification of porcine immunoglobulin G (IgG) subclasses relies on phylogenetic analysis of gene sequences, resulting in a nomenclature that is inapt to predict biological function. Here, we propose a revised, functionality-based nomencl…
HLA-C polymorphisms with susceptibility and protection against acute leukemia in a Moroccan population
BackgroundAcute leukemia (AL) is a malignant hematological disorder, with two main subtypes: acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The incidence rate of AML and ALL is estimated at approximately 2.7 and 1.5 per 100,000 pe…