Cancer immunotherapy has transformed oncology, yet durable benefits remain limited to a subset of patients, and those cases are incompletely explained by tumor-intrinsic biomarkers alone. Growing evidence indicates that the host immune state is a criti…
The B-cell receptor (BCR) repertoire serves as a historical record of immunological events. However, deciphering antigen-specific sequences from this vast dataset remains a challenge, particularly for novel pathogens where prior knowledge is absent. Wh…
The aorta is one of the major arterial vessels in the human body, serving as the principal conduit for the high-velocity blood ejected from the heart. For a long time, its function was largely understood in this limited hemodynamic context. However, wi…
ObjectivesOur aim was to investigate the association between diagnostic delay and the clinical and psychosocial features in patients with psoriatic arthritis (PsA), with particular focus on the mental health, wellbeing, and pain-related mechanisms.Meth…
The therapeutic landscape of advanced melanoma has been transformed by immune checkpoint inhibitors (ICIs); however, primary and acquired resistance remain formidable challenges for a substantial subset of patients. Emerging evidence identifies the CD7…
BackgroundProgrammed death-1 (PD-1) inhibitors are increasingly used in neoadjuvant therapy for low rectal cancer, but complete response and toxicity remain heterogeneous. We developed and validated an albumin-based immune-nutritional score (ABINS) to …
IntroductionGlioblastoma (GBM), the most prevalent and aggressive malignant tumor of the nervous system, presents a formidable clinical challenge due to its rapid progression and extremely poor prognosis. T cell receptor fusion constructs (TRuC) -T cel…
The abscopal effect, defined as the regression of non-irradiated tumors following localized radiotherapy (RT), represents one of the most intriguing manifestations of systemic antitumor immunity. Although traditionally considered a rare and unpredictab…
ObjectiveTo evaluate if transarterial chemoembolization (TACE) combined with Icaritin provides additional survival benefits compared to TACE alone in intermediate-to-advanced hepatocellular carcinoma (HCC) across different Child-Pugh classes.Background…
ObjectiveRecurrence affects 65%-75% of pancreatic cancer (PC) patient post-resection. Established salvage strategies for recurrent PC are lacking, and systemic chemotherapy offers limited survival benefits. This study aimed to evaluate the efficacy and…
