ObjectiveRecurrence affects 65%-75% of pancreatic cancer (PC) patient post-resection. Established salvage strategies for recurrent PC are lacking, and systemic chemotherapy offers limited survival benefits. This study aimed to evaluate the efficacy and…
Psoriasis is primarily characterized by interleukin-23/T helper 17 (IL-23/Th17)-related inflammation, but clinical and epidemiological observations also suggest recurrent temporal features, including seasonal fluctuation, nocturnal symptom exacerbation…
Tumor-associated B cell responses are frequently observed in tumors and their draining lymph nodes, yet their antigen specificities and functional potential remain incompletely defined. Historically, intracellular antigens have been largely disregarded…
BackgroundMolecular histocompatibility assessment using eplet mismatch and Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) scores has improved immunologic risk stratification in kidney transplantation, but its clinical implementation remains li…
ObjectiveTo evaluate the prognostic value of preoperative and postoperative modified Gustave Roussy Immune Score (mGRIm) and dynamic mGRIm trajectories in patients with colorectal cancer (CRC), and to develop internally validated machine-learning model…
ObjectivesThe intermittent administration of parathyroid hormone 1-34 (iPTH) is a bone anabolic therapy with potential for periodontitis treatment, but its immunomodulatory mechanisms remain unclear. This study investigated whether iPTH ameliorates per…
Asthma affects approximately 260 million people globally and causes an estimated 450,000 deaths annually, posing a serious threat to human health and life quality. Current mainstay pharmacotherapies are effective for symptom control but are associated …
IntroductionCutaneous squamous cell carcinoma (cSCC) is a common keratinocyte-derived malignancy whose progression is strongly influenced by the tumor microenvironment. Although recent studies have begun to describe cellular diversity in squamous cell …
The rapid rise of antimicrobial resistance (AMR) has renewed interest in bacteriophages as precision antibacterial agents that can selectively target pathogenic bacteria while limiting disruption of commensal microbiota. However, therapeutic phages are…
BackgroundEndotoxin-driven intestinal inflammation represents a major contributor to impaired barrier function, metabolic inefficiency, and immune dysregulation in both human and animal health. Strategies that reduce luminal inflammatory triggers rathe…
