The rapid rise of antimicrobial resistance (AMR) has renewed interest in bacteriophages as precision antibacterial agents that can selectively target pathogenic bacteria while limiting disruption of commensal microbiota. However, therapeutic phages are…
BackgroundEndotoxin-driven intestinal inflammation represents a major contributor to impaired barrier function, metabolic inefficiency, and immune dysregulation in both human and animal health. Strategies that reduce luminal inflammatory triggers rathe…
Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease primarily affecting the intrahepatic small bile ducts. Although PBC is mainly a hepatobiliary disease, renal abnormalities have been reported in a subset of patients an…
BackgroundThis study investigated the clinical and electrodiagnostic features of vasculitic peripheral neuropathy (VPN) in symptomatic patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) who underwent nerve conduction studies …
Multiple sclerosis is a chronic immune mediated disease in which current disease modifying therapies reduce inflammatory relapses but incompletely address neurodegeneration and remyelination. Natural flavonoids are pleiotropic polyphenols that can modu…
Immunoglobulin light chain (AL) amyloidosis and POEMS syndrome are plasma cell proliferative disorders involving multiple organs and tissues, often presenting with nonspecific clinical manifestations. The co-occurrence of both conditions in a single pa…
ObjectiveTo analyze and summarize the general patterns and key points of treatment for cytokine release syndrome (CRS) induced by immune checkpoint inhibitors (ICIs), and provide references for the differential diagnosis and treatment of this immune-re…
ObjectivesThis study aims to identify novel small-molecule inhibitors that target both PD-L1 and EZH2 to enhance colorectal cancer immunotherapy.MethodsA combination of computer-aided molecular simulation, homogeneous time-resolved fluorescence (HTRF) …
Obesity and chronic pain co-occur at high rates, yet the mechanistic logic that connects metabolic excess to persistent nociception remains fragmented across separate literatures. This review integrates these literatures around a single guiding questio…
ObjectivesPlatelet transfusion refractoriness (PTR) is a common and clinically challenging condition with complex underlying mechanisms. Human leukocyte antigen (HLA) alloimmunization is the principal cause of immune PTR (iPTR), whereas non-HLA antibod…
