Idiosyncratic drug-induced liver injury (iDILI) is not a uniform disease but rather includes a variety of types based on immune, autoimmune, and clinical considerations. This review attempts to close information gaps regarding the role of immunity and …
Background and objectivePolymorphisms of the vitamin D receptor (VDR) gene have been studied in relation to various diseases, including infections. This narrative review aims to summarize the role of VDR polymorphisms in the susceptibility towards pedi…
Epitope spreading has long been proposed as a mechanism contributing to the progression of multiple sclerosis (MS), yet its role in human disease remains incompletely defined. Traditionally viewed as a consequence of antigen release during tissue damag…
BackgroundElectroacupuncture (EA) demonstrates efficacy in alleviating diarrhea-predominant irritable bowel syndrome (IBS-D), yet its mechanisms concerning low-grade intestinal inflammation remain insufficiently elucidated. This study investigated whet…
Immunotherapy has redefined oncology, yet its efficacy remains constrained by low response rates, primary or acquired resistance, immune-related toxicities, and escalating costs. Bacteria-mediated cancer immunotherapy (BCIT), which exploits the intratu…
Current models of microbiome, immune crosstalk center on extracellular receptor-mediated signaling, yet a critical observation challenges this paradigm: intracellular concentrations of gut-derived bacterial metabolites (GDBMs) in CD4+ T cells do not co…
BackgroundVascularized composite allotransplantation (VCA) has emerged as a reconstructive option for complex tissue defects, yet its oncologic long-term safety remains poorly characterized.AimsThis study aims to provide the most comprehensive overview…
Highly sensitized kidney transplant candidates face major barriers to transplantation because broad anti-HLA antibody reactivity substantially limits donor compatibility. We conducted a retrospective cohort study comparing two allocation eras in Pernam…
