BackgroundTriple-negative breast cancer (TNBC) is a highly aggressive subtype characterized by significant inter- and intra-tumoral heterogeneity. Its varied response to radiotherapy limits clinical outcomes, yet the underlying molecular determinants r…
IntroductionGermline predisposition gene mutations may influence outcomes in patients undergoing hematopoietic stem cell transplantation (HSCT).MethodsThis retrospective study of 558 patients undergoing HSCT (allo-HSCT in 557 cases, auto-HSCT in 1 case…
The therapeutic landscape for advanced non-small cell lung cancer (NSCLC) has been transformed by immune checkpoint inhibitors (ICIs), yet significant response heterogeneity necessitates robust, dynamic predictive biomarkers. Conventional tissue-based …
BackgroundSepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Its immunopathology is characterized by a dynamic imbalance between pro-inflammatory and anti-inflammatory responses. Interferon-γ (IFN-γ) and…
BackgroundSevere cutaneous ulceration in antiphospholipid syndrome (APS) with concurrent infection and thrombocytopenia presents a therapeutic dilemma: standard immunosuppression risks worsening infection, while anticoagulation risks hemorrhage. We pre…
Radiation-induced oral mucositis (RIOM) is one of the most common and severe complications in patients with head and neck malignancies undergoing radiotherapy or chemoradiotherapy, with an incidence of 80–100%. More than half of patients develop severe…
BackgroundFor patients with locally advanced esophageal squamous cell carcinoma (ESCC) ineligible for surgery, definitive radiotherapy (RT) is the primary curative-intent treatment, yet outcomes remain suboptimal. The benefit of adding induction immuno…
Musculoskeletal trauma is exceedingly common and experiences a high incidence of complications, including bone non-union. Previous studies have implicated a dysregulated systemic immune response after injury as an important factor contributing to compl…
ObjectiveTo explore the real-world efficacy and safety of telitacicept in patients with systemic lupus erythematosus (SLE).MethodsThis retrospective study included SLE patients treated with telitacicept for at least 3 months at Mianyang Central Hospita…
IntroductionSentinel cells of the airway epithelium are repetitively exposed to RNA virus infections. Here, the production of pathogen-associated molecular patterns (PAMPs) activates the innate immune response (IIR), inducing antiviral defenses, activa…
