Frontiers in Immunology
Complement mediated thrombotic microangiopathy after liver transplantation in combination with a novel C6 variant of uncertain significance
Thrombotic microangiopathies (TMAs) encompass a spectrum of severe pathological conditions mostly characterized by hemolytic anemia, microvascular thrombosis with organ failure, and thrombocytopenia. The etiological spectrum of TMA is diverse, with a n…
How the wild things are: comparative T cell phenotyping and memory T cell identification in wild boar and domestic pigs
Domestic pigs constitute a significant global livestock resource and are increasingly recognized as valuable biomedical models, enabling fundamental research. In contrast, immunological studies on wild boar remain limited. To address this knowledge gap…
The role of extracellular matrix stiffness in regulating fibroblast behaviors and disease progression
As a representative physical factor in the extracellular matrix (ECM), ECM stiffness regulates fibroblast behaviors and contributes to physiological homeostasis and pathological processes. This process relies on mechanosensors, including integrin-based…
Evaluating antioxidant treatment approaches for eosinophilic chronic sinusitis
Chronic rhinosinusitis with eosinophilia (ECRS) is a refractory sinusitis characterized by eosinophilia in the nasal mucosa and peripheral blood. In ECRS, multiple nasal polyps are present in the ethmoid sinuses, and the disease is often accompanied by…
JAK-STAT pathway-associated skin diseases: a refined functional framework for inflammatory skin diseases
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is involved in the pathogenesis of a variety of inflammatory and autoimmune skin diseases, such as atopic dermatitis (AD), psoriasis, alopecia areata (AA),…
Revealing the pathogenesis of autoimmune hepatitis and research progress in drug discovery from hepatic immune cells and intercellular communication signaling mechanisms
Autoimmune hepatitis (AIH) is an immune-mediated chronic liver disease with an increasing incidence. The complex pathogenesis of AIH poses significant challenges for clinical treatment. In recent years, with the introduction of cutting-edge concepts su…
Real-world safety of first-line enfortumab vedotin plus pembrolizumab in advanced urothelial carcinoma: evidence from VigiBase and FAERS
BackgroundCompared with platinum-based chemotherapy, the combination of enfortumab vedotin and pembrolizumab (EV + Pembro) achieves higher durable response rates and improves survival outcomes in patients with locally advanced or metastatic urothelial …
Outcomes of belatacept-based quadruple immunosuppression therapy in kidney transplant recipients with persistent alloimmune response: a single-center observational study
We conducted a retrospective review of adult kidney transplant recipients (KTRs) who received belatacept in addition to calcineurin inhibitors, antimetabolites, and corticosteroids for recurrent or refractory rejection or for persistent donor-specific …
Obinutuzumab versus rituximab-based chemotherapy in high-tumor burden indolent B-cell lymphoma: a real-world comparative study
BackgroundPatients with previously untreated follicular lymphoma (FL) or marginal zone lymphoma (MZL) with high-tumor burden represent a subset with unfavorable prognosis. However, the efficacy of obinutuzumab in this specific high-risk population rema…