Frontiers in Immunology
Case Report: Anti-GABA-B receptor encephalitis with refractory status epilepticus and favorable short-term recovery
Anti-gamma-aminobutyric acid type B receptor (anti-GABA-B receptor) encephalitis is a rare autoimmune limbic encephalitis that frequently presents with seizures and may be associated with malignancy, most commonly small-cell lung cancer. We report a 66…
Deep learning models based on CT predict prognosis in patients with locally advanced esophageal squamous cell carcinoma who received neoadjuvant immunotherapy and chemotherapy
ObjectiveNeoadjuvant immunotherapy and chemotherapy (NICT) has emerged as the standard pharmacological intervention for locally advanced esophageal squamous cell carcinoma (ESCC). However, individual responses to this drug combination vary significantl…
Tocilizumab-induced inflammatory flare in Takayasu arteritis: a case report with exploratory mechanistic findings of Fcγ receptor involvement
BackgroundTo report a refractory Takayasu arteritis (TAK) patient who developed a severe inflammatory flare after tocilizumab (TCZ) therapy and explore the underlying mechanism.Case presentationA 21-year-old female with active TAK received TCZ after in…
Influence of immune checkpoint inhibitor target and timing on combination treatment with antibody-based β-emitting targeted radionuclide therapy across tumor immunogenicity profiles
IntroductionTargeted radionuclide therapy (TRT) and immune checkpoint inhibition (ICI) could be a highly effective combination treatment due to potential synergistic effects. In this study, we investigated two clinically relevant antibody-based radioph…
Acquired immune-mediated thrombotic thrombocytopenic purpura with severe cholestatic liver injury and reversible acute kidney injury after ivonescimab-containing chemoimmunotherapy: a case report and literature review
BackgroundIvonescimab is a PD-1/VEGF bispecific antibody that combines immune checkpoint blockade with anti-angiogenic activity. As PD-1/VEGF-directed regimens enter routine solid-tumor care, rare toxicities at the interface of immune activation, endot…
Spatial transcriptomic analysis identifies a necroptosis-prone thyroid follicular cell state in Hashimoto’s thyroiditis
BackgroundHashimoto’s Thyroiditis (HT) is the leading cause of primary hypothyroidism, characterized by progressive thyroid follicular cell (TFC) loss and diffuse lymphocytic infiltration. While apoptosis dominates TFC death in HT, the role of pro-infl…
Toxicity of BEP chemotherapy in germ cell tumors: focus on immune-mediated bleomycin pulmonary toxicity in comparison with EP and VIP regimens
Bleomycin, etoposide, and cisplatin (BEP) remains the cornerstone of curative first-line treatment for metastatic germ cell tumors (GCTs) across all prognostic risk groups. Although etoposide-cisplatin (EP) and etoposide-ifosfamide-cisplatin (VIP) are …
Immunological profiling and treatment patterns of primary Sjögren’s disease patients with concomitant rheumatoid arthritis: a retrospective cohort study
BackgroundThe coexistence of primary Sjögren’s disease (pSS) and rheumatoid arthritis (RA) is not uncommon, but its immunological characteristics and treatment patterns remain poorly defined. This study aimed to compare the immune profiles and therapeu…
Vγ9Vδ2 T cells in tuberculosis: protective immunity and translational perspectives
BackgroundVγ9Vδ2 T cells constitute the predominant human circulating γδ T cell subset and serve as key mediators of anti-mycobacterial immunity through major histocompatibility complex (MHC)-unrestricted phosphoantigen recognition and rapid effector a…