Aquaculture is vital for global food security. Intensification of farming practices has compromised the welfare of farmed aquatic animals and increased disease outbreaks. Conventional treatments, such as antibiotics, face growing challenges due to anti…
Non-small cell lung cancer (NSCLC) is frequently associated with sarcopenia, a debilitating condition of muscle wasting driven by complex tumor–muscle cross-talk. To unravel the regulatory mechanisms underlying this phenotype, we reconstructed a compre…
Pediatric asthma is a highly heterogeneous inflammatory syndrome characterized by distinct immune endotypes. The inception of asthma predominantly occurs during the first 1,000 days of life, a critical window of immunological plasticity. Within this cr…
BackgroundFish allergy is a potentially severe condition that is frequently managed with broad elimination diets. Molecular allergology may improve risk stratification by distinguishing clinically relevant fish allergy from asymptomatic sensitization. …
The gut and liver form an anatomical and functional unit linked by the portal circulation, the biliary tract, lymphatic drainage, and neuroimmune pathways. In recent years, the classical gut-liver axis has expanded from a predominantly microbial and me…
Background and objectiveDermographism is a frequent clinical finding in patients with chronic spontaneous urticaria (CSU) and may reflect enhanced mast-cell reactivity, increased disease severity, and prolonged disease persistence. This study aimed to …
Autoimmune diseases (ADs) and related immune-mediated inflammatory disorders are characterized by loss of immune tolerance, persistent inflammatory activation, immune-cell imbalance, oxidative stress, and tissue-specific injury. Although conventional i…
BackgroundClear cell renal cell carcinoma (ccRCC) is metabolically primed for ferroptosis, yet the prognostic relevance and mechanistic contribution of ferroptosis-related genes remain incompletely defined. This study aimed to identify ferroptosis-asso…
Autoimmune thyroid diseases (AITDs), mainly Hashimoto’s thyroiditis and Graves’ disease, are common organ-specific autoimmune disorders driven by complex interactions among genetic susceptibility, immune dysregulation, environmental exposure, and micro…
Behçet’s disease (BD) is a complex, relapsing multisystem disorder characterized by autoinflammatory features. Because disease-specific diagnostic biomarkers are lacking and clinical presentation varies according to geographic background and organ invo…
