BackgroundHypomagnesemia is common in patients with cirrhosis. This study aimed to examine the association between serum magnesium levels and the risks of hospital-acquired spontaneous bacterial peritonitis (HA-SBP) and sepsis.MethodsThis retrospective…
ObjectiveTo determine whether observed mechanistic performance of web-enabled large language model (LLM) responses differs across response languages under deployed web conditions and to distinguish such language-associated shifts in relative model perf…
Rituximab is a chimeric anti-CD20 monoclonal antibody widely used in immune-mediated and hematologic diseases, but its efficacy may be limited by the development of anti-rituximab antibodies (ADAs). This narrative review summarizes current evidence on …
BackgroundAntineoplastic drugs are effective for malignant tumours, but they frequently cause severe adverse drug reactions (ADRs), which seriously affect treatment continuity and patient prognosis. Post – marketing real – world safety monitoring is th…
BackgroundSutimlimab, an anti-C1s monoclonal antibody, is approved for the treatment of cold agglutinin disease (CAD). It prevents hemolysis by inhibiting the classical complement pathway. One of its off-target effects may be increasing circulatory com…
BackgroundChildhood asthma has traditionally been characterized as a localized chronic airway inflammatory disease, with structural remodeling viewed merely as a downstream consequence of persistent inflammation. However, clinical evidence revealing si…
Mycobacterium avium subsp. paratuberculosis (MAP) is the primary causative agent of Johne’s disease (JD) in ruminants and bears potential public-health implications. Cumulative epidemiological and molecular evidence implies MAP may contribute to Crohn’…
BackgroundLaryngeal squamous cell carcinoma (LSCC) remains one of the most lethal malignancies of the head and neck region. Tumor metastasis, the primary cause of treatment failure, is intimately linked to the evasion of anoikis. Yet the molecular driv…
Immune memory has long been attributed to adaptive immunity, but trained immunity has broadened this view by showing that innate immune cells can retain altered function after prior stimulation and mount an enhanced response upon rechallenge. In the lu…
BackgroundStress-induced thymic involution is characterized by rapid thymocyte loss and is largely attributed to glucocorticoid signaling. However, the local immune mechanisms involved remain unclear. We investigated the role of the CX3CL1–CX3CR1 axis …
