Many patients with atherosclerotic cardiovascular disease (ASCVD) do not respond well to aspirin therapy. This study employed a multi-omics approach to identify key genes associated with aspirin non-responsiveness, thereby providing potential molecular…
BackgroundRosacea is a chronic inflammatory skin condition. Excessive LL-37 is produced when serine protease kallikrein-5 (KLK5) is hyperactivated, contributing to the inflammatory response in rosacea. Thus, inhibition of KLK5 has the potential to atte…
Although immunocheckpoint blocking therapy has been successful in a variety of cancers, its long-term response is still rare. The difference between initial clinical benefits and persistent disease control reflects the complexity of intratumor immunomo…
IntroductionHereditary angioedema (HAE) is a rare genetic disorder, characterized by unpredictable, potentially life-threatening edema attacks. Treatment options include on-demand treatment (ODT) and long-term prophylactic (LTP) therapy. This study des…
Inflammaging is chronic low-grade inflammation arising from a progressive imbalance between pro-inflammatory and anti-inflammatory immune networks. The rate of inflammaging exhibits marked interindividual variation owing to differences in the pace of b…
Immunomodulatory therapy in sepsis has long failed to deliver consistent clinical benefit, in part because the heterogeneity of host responses and the dynamic nature of disease trajectories have been underestimated. Rather than equating the timing of i…
Thyroid hormone (TH) signaling is widely recognized as an important regulator of skeletal muscle regeneration, yet the mechanisms by which aging alters TH-dependent regenerative responses remain unresolved. Current models generally assume that age-asso…
IntroductionDespite effective antiretroviral therapy, HIV-1 persists as a viral reservoir and remains a major barrier to a durable cure. Reservoir size and dynamics are central determinants of the success of cure strategies. Efforts to characterize and…
BackgroundOsteoporosis is classically defined by reduced bone mass and microarchitectural deterioration, but osteoimmune dysregulation within the bone marrow microenvironment is increasingly recognized as an important contributor to bone loss. The RANK…
IntroductionDiGeorge syndrome (DGS) is an inborn error of immunity characterized by wide phenotypic variability, with a broad spectrum of autoimmune manifestations, including autoimmune cytopenias, thyroiditis, and juvenile idiopathic arthritis (JIA). …
