Immunomodulatory therapy in sepsis has long failed to deliver consistent clinical benefit, in part because the heterogeneity of host responses and the dynamic nature of disease trajectories have been underestimated. Rather than equating the timing of i…
Thyroid hormone (TH) signaling is widely recognized as an important regulator of skeletal muscle regeneration, yet the mechanisms by which aging alters TH-dependent regenerative responses remain unresolved. Current models generally assume that age-asso…
IntroductionDespite effective antiretroviral therapy, HIV-1 persists as a viral reservoir and remains a major barrier to a durable cure. Reservoir size and dynamics are central determinants of the success of cure strategies. Efforts to characterize and…
BackgroundOsteoporosis is classically defined by reduced bone mass and microarchitectural deterioration, but osteoimmune dysregulation within the bone marrow microenvironment is increasingly recognized as an important contributor to bone loss. The RANK…
IntroductionDiGeorge syndrome (DGS) is an inborn error of immunity characterized by wide phenotypic variability, with a broad spectrum of autoimmune manifestations, including autoimmune cytopenias, thyroiditis, and juvenile idiopathic arthritis (JIA). …
IntroductionColorectal cancer (CRC) is a heterogeneous malignancy and a major cause of cancer-related mortality worldwide. Cancer-associated fibroblasts (CAFs) accumulate in tumors and correlate with poor patient survival, suggesting a central role in …
Anti–John Cunningham virus (JCV) serological testing constitutes a cornerstone of progressive multifocal leukoencephalopathy (PML) risk assessment in patients receiving natalizumab for multiple sclerosis (MS). Existing PML risk stratification algorithm…
BackgroundLung squamous cell carcinoma (LUSC) represents a predominant subtype of non-small cell lung cancer (NSCLC) with scarce effective targeted therapeutic options, rendering immune checkpoint inhibitor (ICI)-based regimens the standard first-line …
Acute respiratory distress syndrome (ARDS) is a life-threatening condition with high mortality and limited effective pharmacotherapies. Accumulating evidence has established mitochondrial dysfunction as a central pathogenic hub in ARDS. Injured mitocho…
Curr Opin Immunol. 2026 Jul 28;102:102830. doi: 10.1016/j.coi.2026.102830. Online ahead of print. ABSTRACT Over the last two years, inflammatory dermatology has undergone a transition from morphology-based classification toward pathway-driven immune endotyping. Atopic dermatitis, psoriatic disease, and hidradenitis suppurativa have emerged as paradigmatic models of this transition, illustrating how epithelial dysfunction, involving autoinflammation and adaptive immunity, … Read more
