BackgroundLaryngeal squamous cell carcinoma (LSCC) remains one of the most lethal malignancies of the head and neck region. Tumor metastasis, the primary cause of treatment failure, is intimately linked to the evasion of anoikis. Yet the molecular driv…
Immune memory has long been attributed to adaptive immunity, but trained immunity has broadened this view by showing that innate immune cells can retain altered function after prior stimulation and mount an enhanced response upon rechallenge. In the lu…
BackgroundStress-induced thymic involution is characterized by rapid thymocyte loss and is largely attributed to glucocorticoid signaling. However, the local immune mechanisms involved remain unclear. We investigated the role of the CX3CL1–CX3CR1 axis …
As the stable and conserved circular non-coding RNAs, circular RNAs (circRNAs) have assumed growing significance in regulating breast cancer immunity and immunotherapy. This review focuses on elucidating the molecular mechanisms through which circRNAs …
BackgroundLocalized scleroderma (LoS) is an autoimmune disorder leading to skin sclerosis and subcutaneous tissue atrophy. Apart from the disfiguring craniofacial lesions, the extracutaneous involvement in LoS has been increasingly recognized and studi…
BackgroundLaryngeal squamous cell carcinoma (LSCC) remains a major cause of cancer-related mortality among head and neck malignancies. The tumor immune microenvironment plays a critical role in determining disease outcome; however, the specific immune …
WWP2 is a NEDD4-family HECT E3 ubiquitin ligase with emerging relevance to immune regulation and cancer immunity. Although WWP2 has been widely studied in tumor growth, fibrosis, and cell signaling, its immune functions are less consistently integrated…
BackgroundThe freshwater gastropod Biomphalaria glabrata is the major intermediate host of Schistosoma mansoni, the causative agent of human schistosomiasis. Elucidating the molecular basis of snail resistance to schistosomes is essential for understan…
BackgroundGout is an inflammatory arthritis characterized by hyperuricemia in humans. Male patients with gout or hyperuricemia have a wide range of reproductive health challenges. However, research on the sexual and reproductive health of male patients…
