BackgroundCutaneous melanoma is an aggressive malignancy characterized by a high metastatic potential and variable response to immune checkpoint blockade (ICB). The extracellular matrix protein proline/arginine-rich end leucine-rich repeat protein (PRE…
IntroductionOral squamous cell carcinoma (OSCC) is a major concern due to high recurrence, therapeutic resistance, and mortality. Increasing evidence indicates that oral microbiome dysbiosis contributes to OSCC development, yet comprehensive multi-coho…
BackgroundUlcerative colitis (UC) is a chronic, immune-mediated inflammatory bowel disorder, and macrophages are essential for maintaining intestinal mucosal balance during UC. Long intergenic non-coding RNA–erythroid prosurvival (lincRNA-EPS) is a nov…
BackgroundCancer stem cells (CSCs) are critical drivers of tumor progression and therapeutic resistance in non-small cell lung cancer (NSCLC). However, how CSCs remodel the immunosuppressive tumor microenvironment (TME) of NSCLC remains largely unclear…
To describe the clinical outcomes of transitioning from efgartigimod to tacrolimus in chronic inflammatory demyelinating polyneuropathy (CIDP) patients. Six patients who completed the ADHERE trial and maintained clinical stability during the open-label…
J Immunol. 2026 Aug 29;215(9):vkag233. doi: 10.1093/jimmun/vkag233. ABSTRACT Psoriasis is a chronic, immune-mediated inflammatory skin disease affecting at least 2% of the global population. Papaverine, an alkaloid with known anti-inflammatory, anti-cancer, and RAGE-antagonistic properties, has not been previously evaluated for anti-psoriatic activity. This study investigated the protective effects and mechanisms of papaverine in an imiquimod … Read more
ObjectiveAdvanced melanoma remains a major clinical challenge due to resistance to immune checkpoint inhibitors (ICIs, e.g., anti PD-1). Astragalus Polysaccharide (APS) is a clinically approved immunomodulator for cancer treatment. However, its interac…
Pediatric ulcerative colitis (PUC) is a chronic, immune-mediated inflammatory disease that exhibits different clinical characteristics and pathogenesis from those in adults. PUC is more severe and has a wider lesion range. The main manifestations inclu…
CD8+ TRM cells are indispensable for continuous surveillance of tissues and direct elimination of invading pathogens through a diverse range of effector mechanisms. They balance adhesion, metabolic adaptation, and commensal tolerance against the capaci…
