Publicaciones
The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects
Steady-state antigen recognition triggers tolerant CD8+ T cell states that restrain autoimmunity and limit anti-cancer immunity. The relationship between tolerant states and other differentiation states remains unclear. Van Der Byl et al. demonstrate t…
Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification
In contrast to other immune cell lineages, little is known about how eosinophils develop, expand, and mature in health and disease. Using single-cell RNA sequencing, high-dimension flow cytometric screening, and IL-5Rα reporter mice, Jorssen, Van Hulst…
Sequence of androgen receptor-targeted vaccination with androgen deprivation therapy affects anti-prostate tumor efficacy
Rationale
Androgen deprivation therapy (ADT) is the primary treatment for recurrent and metastatic prostate cancer. In addition to direct antitumor effects, ADT has immunomodulatory effects such as promoting T-cell infiltration and enhancing antigen p…
Developing a membrane-proximal CD33-targeting CAR T cell
Background
CD33 is a tractable target in acute myeloid leukemia (AML) for chimeric antigen receptor (CAR) T cell therapy, but clinical success is lacking.
Methods
We developed 3P14HLh28Z, a novel CD33-directed CD28/CD3Z-based CAR T cell derived from …
Clinical biomarker profiles reveals gender differences and mortality factors in sepsis
BackgroundSepsis is a major contributor to global morbidity and mortality, affecting millions each year. Notwithstanding the decline in sepsis incidence and mortality over decades, gender disparities in sepsis outcomes persist, with research suggesting…
COVID-19 PBMCs are doubly harmful, through LDN-mediated lung epithelial damage and monocytic impaired responsiveness to live Pseudomonas aeruginosa exposure
IntroductionAlthough many studies have underscored the importance of T cells, phenotypically and functionally, fewer have studied the functions of myeloid cells in COVID disease. In particular, the potential role of myeloid cells such as monocytes and …
A helping HAND: therapeutic potential of MAGL inhibition against HIV-1-associated neuroinflammation
BackgroundHuman immunodeficiency virus (HIV) affects nearly 40 million people globally, with roughly 80% of all people living with HIV receiving antiretroviral therapy. Antiretroviral treatment suppresses viral load in peripheral tissues but does not e…
Lactate and lactylation in macrophage metabolic reprogramming: current progress and outstanding issues
It is commonly known that different macrophage phenotypes play specific roles in different pathophysiological processes. In recent years, many studies have linked the phenotypes of macrophages to their characteristics in different metabolic pathways, s…
Sex differences in immune protection in mice conferred by heterologous vaccines for pneumonic plague
BackgroundYersinia pestis is the etiological agent of plague, which can manifest as bubonic, septicemic, and/or pneumonic disease. Plague is a severe and rapidly progressing illness that can only be successfully treated with antibiotics initiated early…