IntroductionIn thrombi, fibrin formation is accompanied by neutrophil activation, which leads to the release of neutrophil extracellular traps (NETs). Citrullination is a post-translational modification of arginine catalyzed by peptidylarginine deimina…
ObjectiveThis report describes the diagnostic and therapeutic management of Sweet’s syndrome (SS) presenting as a painful forehead plaque in a patient with refractory ulcerative colitis (UC) during apparent endoscopic remission. It highlights the assoc…
IntroductionSalmonella and Shigella infections are two of the leading causes of global diarrheal deaths in children younger than 5 years. Licensed vaccines against Salmonella Typhi have been shown to be effective, and other Salmonella and Shigella vacc…
Powassan virus (POWV) is a tick-borne Orthoflavivirus transmitted by Ixodes tick species. POWV causes fatal encephalitis in approximately 10-30% of neurological cases, and long-lasting neurological sequelae in approximately 50% of survivors. POWV entry…
Multiple myeloma (MM) persists within a specialized bone marrow niche in which malignant plasma cells, immune dysfunction, inflammatory signaling, and metabolic stress reinforce one another. To resolve this ecosystem at compartment-level resolution, we…
IntroductionThe resurgence of pertussis poses a severe threat to infants under 3 months of age due to an inherent early-life “immunity gap.” While maternal immunization with the tetanus, diphtheria, and acellular pertussis (Tdap/Tdacp) vaccine effectiv…
BackgroundBenefit from first-line immunotherapy-based treatment in advanced biliary tract cancer (BTC) is heterogeneous, and selection biomarkers are lacking. We investigated whether genomic features could stratify benefit from intensified immunotherap…
Mucosal Immunol. 2026 Jul 25:100390. doi: 10.1016/j.mucimm.2026.100390. Online ahead of print. ABSTRACT B cells play a crucial role in maintaining immune homeostasis at mucosal surfaces, including those of the gastrointestinal (GI) tract. Perturbed humoral immunity and antibody-mediated functions of B cells are well described in patients with chronic GI inflammatory diseases. However, our understanding of … Read more
J Immunol. 2026 Jul 10;215(7):vkag175. doi: 10.1093/jimmun/vkag175. ABSTRACT The adaptor protein SLP-76 plays a critical role in T-cell receptor signaling and immune activation, yet its relevance in inflammatory bowel disease (IBD) remains unclear. Although calcineurin inhibitors such as cyclosporine A (CsA) are used in severe ulcerative colitis, voclosporin (VCS), a novel calcineurin inhibitor approved for … Read more
J Immunol. 2026 Jul 10;215(7):vkag197. doi: 10.1093/jimmun/vkag197. ABSTRACT Platelets are small, anucleate cells derived from megakaryocytes and are known for their essential role in hemostasis. Over the past decade, they have also emerged as important immune modulators, able to affect viral replication and leukocyte behavior. Most studies on platelets and viral infections have been focused … Read more
