IntroductionKidney transplantation is the preferred treatment for end-stage renal disease, but immune-mediated graft dysfunction remains a major barrier to long-term success. Conventional indicators such as serum creatinine and proteinuria are not immu…
BackgroundProteins expressed on the surface of Plasmodium falciparum-infected erythrocytes (IEs) are targets of immunity. Previous studies described that IEs from young children are more readily recognized than IEs from older children. Here, we aimed t…
Schistosomiasis is a parasitic disease caused by trematodes of the genus Schistosoma, typically found in tropical and subtropical freshwater environments. Recognized by the World Health Organization as a major emerging disease, schistosomiasis is chara…
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune central nervous system (CNS) disorder mediated by antibodies against the GluN1 subunit of the NMDA receptor. Sjögren’s disease (SjD) is a systemic autoimmune disorder that involves…
IntroductionUmbilical cord blood (UCB) is an attractive source of natural killer (NK) cells for the development of allogeneic ‘off-the-shelf’ cancer immunotherapies. This is due to the relatively high proportion of highly proliferative NK cells compare…
ObjectivePancreatic cancer is one of the most aggressive malignancies with a poor prognosis and limited treatment options. This study aimed to evaluate the efficacy of a dendritic cell (DC) vaccine pulsed with mucin 1 (MUC1) peptide antigens in the imm…
AimNeutralizing anti-drug antibodies (ADA) limit therapy efficacies significantly. Pegunigalsidase alfa is a newly approved drug for the treatment of Fabry disease. The increased plasma half-life due to PEGylation interferes with ADA measurements inclu…
IntroductionMany cytokines have been used as candidate biomarkers of acute graft-versus-host disease (aGVHD). Among these, the roles of interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-8, IL-10, IL-17A, and IL-1β in aGVHD remai…
ObjectiveThis study aimed to compare the risk of developing systemic autoimmune diseases (SADs) among pediatric patients with juvenile idiopathic arthritis (JIA) treated with tumor necrosis factor inhibitors (TNFi) versus interleukin-6 inhibitors (IL-6…
