Type 2 inflammatory diseases are often grouped together as a single immunological entity, driven by shared cytokines and overlapping pathways. This framework has led to the development of biologic therapies targeting upstream epithelial-derived “alarmi…
Spousal living donation expands access to kidney transplantation. Husband-to-wife kidney transplantation (HTW) may have a distinct immunologic context when the recipient has had pregnancies with the current donor, because maternal exposure involves the…
The development of effective vaccines against the opportunistic pathogen Pseudomonas aeruginosa (Pa) remains a critical public health priority for susceptible individuals due, in part, to the pathogen’s intrinsic resistance mechanisms. This study evalu…
BackgroundClinical and biological consequences of accelerated immune aging are substantial, with growing evidence of increased risk of non-communicable diseases (NCD) among people living with HIV (PLHIV). However, there is limited understanding of reli…
Anti-metabotropic glutamate receptor 1 (mGluR1) encephalitis is a rare autoimmune disorder affecting both the central and peripheral nervous systems, typically characterized by a subacute cerebellar syndrome. Its effective treatment remains undefined. …
Relapse of acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) affects 40–50% of recipients and remains the leading cause of posttransplant mortality; median overall survival is approximately 5 months and 1…
ObjectivesThis study aims to discover and characterize novel D(+)-biotin-conjugated PD-L1 inhibitors for precision tumor-targeted cancer immunotherapy.MethodsIntegrated strategies, including computer-aided molecular simulation, antiproliferative activi…
Ulcerative colitis (UC) is a chronic, relapsing inflammatory disorder of the colonic mucosa, whose pathogenesis is intricately linked to metabolic reprogramming within both immune and epithelial compartments. The mechanistic target of rapamycin (mTOR) …
N6-methyladenosine (m6A), the most abundant internal RNA modification in eukaryotic cells, has emerged as a critical regulator of antiviral host defense. Increasing evidence indicates that m6A functions beyond conventional post-transcriptional regulati…
Autoimmune uveitis (AU) is a vision-threatening intraocular inflammatory disease characterized by disruption of ocular immune privilege, blood-retinal barrier (BRB) dysfunction, and progressive immune-mediated retinal injury. Although corticosteroids a…
